Hepatocellular Carcinoma, Non-cirrhotic Liver
Conditions
Brief summary
Background: Majority of liver transplantation (LT) recipients for hepatocellular carcinoma (HCC) were concomitant with liver cirrhosis, while few researches focusing on recipients without cirrhosis. Here we aim to investigate the prognosis of non-cirrhosis HCC recipients, expecting to provide theoretical basis for further improvement of these patients. Methods: This retrospective study analyze outcomes between adult HCC recipients arising in non-cirrhotic and cirrhotic liver from two national databases (CLTR and UNOS, January 2015 to December 2020). Based on important variables, 1:2 and 1:1 propensity score matching (PSM) were performed respectively.
Interventions
None listed
Sponsors
Xiao Xu
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* liver transplants, performed from January 2015 to December 2020
Exclusion criteria
* pediatric LT; LT for non-tumor lesions; LT for other malignant tumors (cholangiocarcinoma, carcinoma of gallbladder, mixed carcinoma, and secondary tumors); re-transplantation or combined liver-kidney transplantation; incomplete laboratory or clinical data; death within 1 week due to post-operative hemorrhage after LT.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative complications were evaluated by postoperative imaging and serological examination | 3 months | Including rejection after liver transplantation, vascular complications, new metabolic diseases and so on |
| The overall survival rate was evaluated by follow-up investigation and outpatient review | 1-3 years | — |
| The tumor-free survival rate was evaluated by follow-up investigation and outpatient review | 1-3 years | — |
Countries
China
Outcome results
None listed