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PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06364514
Enrollment
50
Registered
2024-04-15
Start date
2024-08-20
Completion date
2026-10-01
Last updated
2025-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia

Brief summary

To determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (CMC) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.

Interventions

OTHERClinical Stability Assessment

Base total days of antibiotics on clinical stability vs utilizing predetermined total days of antibiotics

Sponsors

Boston Children's Hospital
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
2 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

* Admitted to the Complex Care Service at Boston Children's Hospital with a provider diagnosis of pneumonia * Started on antibiotics by the provider team * Ages 2-25 years old

Exclusion criteria

* Patients initially admitted to the intermediate care unit or ICU due to increased respiratory support needs

Design outcomes

Primary

MeasureTime frameDescription
Proportion of eligible patients who consent to participate in the intervention48 hoursCaregiver and medical provider acceptability
Rate of persistent and worsening respiratory symptoms measured by patient's clinical status; the rate of emergency department revisit or hospital readmission within 1 week of antibiotic discontinuation1 weekPatient Safety Outcomes

Secondary

MeasureTime frameDescription
Median days of antibiotics received for patients in the intervention group as well as from historical control group30 daysPneumonia antibiotic duration

Countries

United States

Contacts

Primary ContactKathleen Snow, MD
kathleen.snow@childrens.harvard.edu6178238926

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026