Lichen Planus, Oral
Conditions
Keywords
seleinum, Antioxidant, Glutathione-S-transferases, Reactive oxygen species
Brief summary
evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.
Detailed description
The signs and symptoms of the oral lichen planus lesion. 2-The associated oral symptoms. 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis .
Interventions
DRUGTriamcinolone Acetonide 0.1% Oint
RCT
DRUGTacrollimus Topical
RCT
DRUGSelenium
RCT
DRUGSelenium & Triamcinolone Acetonide 0.1% Oint
RCT
DRUGSelenium& Tacrollimus topical
RCT
Sponsors
Sphinx university
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* clinical diagnosis of OLP
Exclusion criteria
1. lichenoid reaction from medication ' . 2. any systemic autoimmune disease 3. Pregnancy 4. smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| to assess a visual analog scale (VAS)of the oral lichen planus lesion | baseline, 1, 3 and 6 months after treatment | qualitative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to assess The associated Oral Disease Severity Score 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis | baseline, 1, 3 and 6 months after treatment | qualitative ,and quantitiave |
| Biochemical evaluation of salivary Glutathione level using (ELISA) | baseline, 1, 3 months after treatment | Quantity |
Countries
Egypt
Outcome results
None listed