Cancer, Fertility Issues
Conditions
Keywords
fertility preservation, cancer
Brief summary
To explore whether there is a significant difference in the cumulative live birth rate and maternal and child health outcomes between cancer patients who undergo or do not undergo fertility preservation before receiving anti-tumor treatment and non-cancer patients who undergo assisted reproductive technology treatment/natural pregnancy. This study will be conducted in the Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University. 2800 women diagnosed with malignant cancers who has desire to reproduce will be enrolled in this study. Statistical analysis of the data will be performed.
Detailed description
The number of new cancer cases among Chinese women in 2020 will be 2.09 million, showing a trend in younger age at the time of diagnosis. Incomplete statistics show that 25%\ 30% of young breast cancer patients in China Need for fertility preservation. In this study, we want to answer the question: Does fertility preservation affect the prognosis in female cancer patients. This study will be conducted in the Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University. 2800 women diagnosed with malignant cancers who has desire to reproduce will be enrolled in this study. If a female tumor patients (focusing on: breast cancer, hematological diseases/lymphoma, gynecological tumors (ovarian borderline tumors, etc.), nasopharyngeal cancer, colorectal cancer, etc.) have a desire to reproduce in the future, she would considered for enrollment. After being admitted into this study, according to the patients'own will, she will receive long term observation or fertility preservation followed by long term observation. Cumulative live birth rate, perinatal and perinatal complications, and offspring health of women who have or have not received fertility preservation before anti-tumor treatment and who have no tumor and who normally receive assisted reproductive technology treatment/natural pregnancy are all recorded, to assess the impact of the current new anti-tumor treatment on female fertility and offspring health.
Interventions
OTHERfertility preservation
If a patient have a desire to fertility preservation, oocyte freezing or embryo freezing will be offered.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Inclusion criteria
1. Tumor confirmed (main focus: breast cancer, hematological disease/lymphoma, gynecological tumor (ovarian cancer), boundary tumors, nasopharyngeal cancer, colorectal cancer, and other tumors that require anti-tumor treatment; 2. Having a desire for future fertility(including women who have already given birth); 3. Age: 20-40 years old (patients planning to freeze their eggs are ≤35 years old, and those planning to freeze their embryos are ≤40 years old); 4. Consent.
Exclusion criteria
1. Patients with congenital or acquired uterine abnormalities, severe intrauterine adhesions, and other diseases that have a clear impact on pregnancy; 2. Those with assisted reproductive technology and pregnancy contraindications; 3. Tumors that are not suitable for pregnancy after multidisciplinary discussions on tumor fertility; 4. Clinical diagnosis of POI (premature ovarian insufficiency).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 5-year cumulative live birth rate | 5 years | 5-year cumulative live birth rate for female patients who reproduce |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ovarian function(AMH levels) | 5 years | AMH levels of all patients |
| Ovarian function(AFC counts) | 5 years | AFC counts of of all patients |
| Newborn malformation rate | 5 years | Newborn malformation rate for female patients who reproduced |
| Tumor recurrence rate | 5 years | Tumor recurrence rate of all participants |
| Tumor survival rate | 5 years | Tumor survival rate of all participants |
Countries
China
Outcome results
None listed