Zhejiang University
Conditions
Keywords
liver transplantation; propensity score matching; split; whole; hepatocellular carcinoma; prognosis
Brief summary
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also . Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial. This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.
Detailed description
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also . Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial. This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.
Interventions
OTHERNo intervention factor
No intervention factor
Sponsors
Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. ≥ 18 years old 2. Received a liver transplantation between 2018 and 2022 (3) Liver transplantation was performed by SLT or WLT
Exclusion criteria
1. Re-LT 2. Multiorgan transplantation 3. Survival≤one week after LT 4. Incomplete data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative complications were evaluated by postoperative imaging reports and serological indicators | Jan.1 2018-Dec.31 2022 | Including rejection, emerging metabolic diseases, infections |
| The survival rate of each group was evaluated by follow-up survey and K-M curve | Jan.1 2018-Dec.31 2022 | Including overall survival rate and/or tumor free survival rate |
Countries
China
Outcome results
None listed