Cancer, Coronary Artery Disease
Conditions
Keywords
Time, Percutaneous coronary intervention, Cancer surgery
Brief summary
To evaluate the association between time from PCI to cancer surgery and cardiovascular and oncologic outcomes in early-stage cancer patients, A retrospective, population-based cohort study was conducted using data from the Korean National Health Insurance Service (K-NHIS) database.
Detailed description
Early-stage-cancer patients with a history of PCI who underwent cancer surgery (N = 3621) were included. The patients were divided into two groups based on the time between the dates of PCI and cancer surgery (<12 months and ≥12 months). Patients were stratified into early-surgery and late-surgery, defined as patients who underwent surgery ≥1 and <1 month after cancer diagnosis. Outcomes included bleeding, spontaneous myocardial infarction (MI), repeat revascularization, cancer recurrence, and death.
Interventions
None listed
Sponsors
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* men and women aged ≥18 years who were diagnosed with cancer and underwent cancer surgery within 1 year following diagnosis. * patients who underwent PCI (procedure code: M6551-M6572, O1640-O1649, OA640-OA649) prior to the cancer surgery
Exclusion criteria
* participants who received neoadjuvant or adjuvant treatment for cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurence of Bleeding | up to 5 years | Bleeding requiring transfusion was defined by the transfusion codes (X2021, X2022, X2031, X2032, X2091, X2092, X2111, X2112, X2131, X2132). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurence of Spontaneous myocardial infarction | up to 5 years | Spontaneous myocardial infarction (MI) was defined as hospitalization for MI (ICD-10 codes I21 and I22) |
| Occurence of Repeat revascularization | up to 5 years | Repeat revascularization was defined as the presence of a procedure code after cancer surgery. |
| Occurence of Cancer recurrence | up to 5 years | Cancer recurrence was defined as the presence of chemotherapy and/or radiation therapy that began more than 6 months after surgery completion. |
| Occurence of All cause death | up to 5 years | Vital status was obtained from death certification collected by Statistics Korea at the Ministry of Strategy and Finance of South Korea. |
Outcome results
None listed