The Effects of Pain and Pain Relief on Peripheral Nerve Excitability

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06356376

Enrollment

Registered

2024-04-10

Start date

2023-12-20

Completion date

2024-04-30

Last updated

2024-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia

Keywords

Pain, Excitability, Microneurography, Autonomic nervous system

Brief summary

This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief. The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.

Interventions

DEVICEHeat Stimulation

Heat stimulation at a painful, but to the subject tolerable level.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy Participants able to give informed consent.

Exclusion criteria

* Chronic pain conditions * Neurological or Psychiatric disease * Other major diseases * Pain medication within the last 24 hours

Design outcomes

Primary

Measure	Time frame	Description
C-fiber excitability	Through study completion, an average of 6 months	Changes in C-fiber excitability measured in latency changes after electrical stimulation with a paired pulse protocol compared to an unpaired electrical stimulus.

Secondary

Measure	Time frame	Description
Action potential duration (ms)	Through study completion, an average of 6 months	Averaged analysis from repeated measures of a single nerve fiber signal.
Action potential amplitude (V)	Through study completion, an average of 6 months	Averaged analysis from repeated measures of a single nerve fiber signal.
Heart-rate variability (ms)	Through study completion, an average of 6 months	Comparison of heart-rate variability during experimental pain stimulation and during pain relief.
Blood pressure variability (mmHg)	Through study completion, an average of 6 months	Changes in continuous blood pressure measurement averages during experimental pain stimulation and during pain relief..
Sympathetic Skin Response (V)	Through study completion, an average of 6 months	Amplitude of Sympathetic skin response during pain stimulation and relief respectively.

Countries

Denmark

Contacts

Primary ContactAlexander G Kristensen, MD, PhD

alexgramm@clin.au.dk+45 93 52 28 64

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026