Type 1 Diabetes
Conditions
Brief summary
Epicardial fat thickness, carotid intima-media thickness, and augmentation index from arterial stiffness indicators are increased in children with T1DM compared to the healthy control group. These results support the idea that children with T1DM present significant changes in important subclinical indicators for the development of cardiovascular disease.
Interventions
DEVICEEchocardiography
cardiovascular evaluation
Sponsors
Ankara City Hospital Bilkent
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
8 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
1. type T1DM patients 2. body mass index (BMI) between the 5th and 85th percentile according to age and gender 3. having T1DM for at least 2 years 4. ages 8-18 years
Exclusion criteria
1. having any chronic diseases other than T1DM 2. presence of a congenital and/or acquired heart disease, hypertension etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epicardial fat thickness | january 2023-june 2023 | Epicardial fat thickness was measured with Echocardiography as milimeter. Epicardial fat was identified as the echo-free space between the outer wall of the myocardium and the visceral layer of pericardium. The values of children with type 1 DM were compared with healthy children. Values are given as mean and standard deviation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| carotid intima-media thickness | january 2023-june 2023 | carotid intima-media thickness were measured by echocardiography machine as milimeter. cIMT is defined as the distance between the first echogenic line (lumen-intima interface) and the second echogenic line (media-adventitia interface) of the far wall. The values of children with type 1 DM were compared with healthy children. Values are given as mean and standard deviation. |
| arterial stiffness parameters such as pulse wave velocity, augmentation index | january 2023-june 2023 | cuff-based validated oscillometric Mobil-O-Graph device (I.E.M., GmbH, Aachen, Germany) was used to these parameters. Data from the Mobil-O Graph device was exported and analyzed using Hypertension Management Software Client-Server version 5.2.3. The values of children with type 1 DM were compared with healthy children. Values are given as mean and standard deviation. |
Countries
Turkey (Türkiye)
Outcome results
None listed