Dexmedetomidine, Drug Use
Conditions
Brief summary
Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation
Interventions
Dexmedetomidine (Precedex) loadings of 1 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
DRUGGROUP B
Dexmedetomidine (Precedex) loadings of 0.5 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
DRUGGROUP C
Dexmedetomidine (Precedex) loadings of 0.25 μg/kg, then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy
Exclusion criteria
history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC \< 70%
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation by the end study | UP TO 6 HOURE | PaO2/Fraction of inspired oxygen |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative dynamic lung compliance | up to 6 hours | tidal volume/ (peak airway pressure -PEEP) |
| Intraoperative static lung compliance | UP TO 6 HOURE | Tidal volume/ (plateau pressure - PEEP) |
| Physiological dead space | UP TO 6HOURE | 1.14 (PaCO2-EtCO2)/ PaCO2-0.005 |
Countries
Egypt
Contacts
Primary ContactAmr S Wahdan, MD
Outcome results
None listed