Parkinson Disease(PD)
Conditions
Keywords
Gait, Cycling training, Treadmill training, Dual-task walking, Dual-task cycling
Brief summary
Motor impairment in lower extremities is common in individuals with Parkinson disease (PD). Development sensitive test for early motor deviations is important. Conventional walking test cannot induce the PD related motor impairments, such as freezing of gait. Therefore, finding a safe substitute test to induce PD related motor impairments is important. Studies showed that working memory related dual task walking was a sensitive test for PD. However, the optimal cognitive test needs to be clarified. Studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking. Therefore, dual task cycling test is potential to be a safe and sensitive testing model. Studies showed that exercise could improve cognitive function and induce brain plasticity. Dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall. Whether the added cognitive task could improve to detriment brain plasticity in PD should be investigated. Transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity. The purpose of this three-year project is to develop PD-sensitive. The purposes of the first year are to translate the dual task walking test to dual task cycling test, and to establish the reliability of the dual task cycling test. The purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between PD and healthy control people. The purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with PD on motor cortex plasticity, dual task performance, and ambulation ability.
Interventions
OTHERCognitive cycling training
Cycling training conducted with cognitive tasks
OTHERCognitive treadmill training
Treadmill training conducted with cognitive tasks
Sponsors
Chang Gung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Health subjects:
Exclusion criteria
* Musculoskeletal injuries on legs. * Osteoporosis. PD subjects: Inclusion Criteria: \- Clinical diagnosis of Parkinson disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reaction Time | Baseline, 4 weeks and 8 weeks. | The duration between the onset of task start time and the participant's response to it, typically expressed in second (s). |
| Balance Performance | Baseline, 4 weeks and 8 weeks | Measured by the duration the stance can be maintained, typically expressed second. |
| Walking Speed | Baseline, 4 weeks and 8 weeks | The time taken by participants to walk a standardized distance, typically expressed in centimeters per second (cm/s). |
| Step Length | Baseline, 4 weeks and 8 weeks | The linear distance between the two ankles, typically expressed in centimeters(cm). |
| Step Time | Baseline, 4 weeks and 8 weeks | The duration taken for one complete step, measuring from foot-off of one foot to the next foot-off of the same foot, usually expressed in seconds. |
| Power Spectral Density (PSD) | Baseline, 4 weeks and 8 weeks. | Quantifies the power of EEG signals within specific frequency bands (e.g., delta, theta, alpha, beta, and gamma) over a period. |
| Task Accuracy | Baseline, 4 weeks and 8 weeks. | The percentage of correct responses or actions made by participants in response to walking or cycling tasks. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Single Support Time | Baseline, 4 weeks and 8 weeks | The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle. |
| Swing Time | Baseline, 4 weeks and 8 weeks | The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds. |
| Stance Time | Baseline, 4 weeks and 8 weeks | The portion of the gait cycle when the foot is in contact with the ground, supporting body weight. It's typically expressed as a percentage of the total gait cycle or in seconds |
| Cadence | Baseline, 4 weeks and 8 weeks | The number of steps an individual takes per minute, providing an overview of gait speed and rhythm, , expressed as steps per minute. |
| Heart rate | Baseline | The number of heartbeats per minute on resting, walking or cycling tasks. |
| Double Support Time | Baseline, 4 weeks and 8 weeks | The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds. |
Countries
Taiwan
Outcome results
None listed