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Exercise in Pregnancy and Risk of Postpartum Depression

Exercise in Pregnancy and Risk of Postpartum Depression

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06355375
Enrollment
398
Registered
2024-04-09
Start date
2024-03-22
Completion date
2025-12-01
Last updated
2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Pregnancy Related

Brief summary

The prevalence of postpartum depression (PPD) varies between 11.9% and 19.2% during the perinatal period. PPD refers to minor and major depression incidents that occur during pregnancy or shortly after (up until 12 months after birth). The symptoms of PPD embrace feeling sad or having a depressed mood, being uninterested in the new-born, unreasonable crying and fear of injuring or harming the baby. Consequently, PPD can negatively impact the mother's well-being and the baby's development. The impact on a child can be short for cognitive and motor development . Although medication is a feasible alternative, many women have constraints due to continuing breastfeeding. Therefore, exercise can be an alternative that could help to deal with PPD. Exercise can be used as a preventive or treatment of mild depression at an early stage and as an addition to a treatment plan for major depressive disorder. Exercising during pregnancy and postpartum improves psychological health and also benefits physical fitness, weight gain control and the prevention or reduction of musculoskeletal discomfort and pain. Therefore, the American College of Obstetrics and Gynaecologists has recommended that women during pregnancy and postpartum engage in moderate-intensity physical activity almost every day for 30 min a day

Detailed description

The prevalence of postpartum depression (PPD) varies between 11.9% and 19.2% during the perinatal period. PPD refers to minor and major depression incidents that occur during pregnancy or shortly after (up until 12 months after birth). The symptoms of PPD embrace feeling sad or having a depressed mood, being uninterested in the new-born, unreasonable crying and fear of injuring or harming the baby. Consequently, PPD can negatively impact the mother's well-being and the baby's development. The impact on a child can be short for cognitive and motor development . Although medication is a feasible alternative, many women have constraints due to continuing breastfeeding. Therefore, exercise can be an alternative that could help to deal with PPD. Exercise can be used as a preventive or treatment of mild depression at an early stage and as an addition to a treatment plan for major depressive disorder. Exercising during pregnancy and postpartum improves psychological health and also benefits physical fitness, weight gain control and the prevention or reduction of musculoskeletal discomfort and pain. Therefore, the American College of Obstetrics and Gynaecologists has recommended that women during pregnancy and postpartum engage in moderate-intensity physical activity almost every day for 30 min a day

Interventions

aerobic exercise

Sponsors

Federico II University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

Exercise during pregnancy

Eligibility

Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No

Inclusion criteria

* singleton gestation * low risk pregnancy * age between 20 and 40

Exclusion criteria

* high risk pregnancy * multiple gestation * prior post partum depression * any psychiatric disase * controindication for exercise * lung or heart disease * prior preterm birth * IVF pregnancy * women who already perform agonistic sport activity

Design outcomes

Primary

MeasureTime frameDescription
edinburgh depression scale3 months after deliveryEdinburgh Postnatal Depression Scale (EDPS)

Secondary

MeasureTime frameDescription
Postpartum depression3 months after deliveryDSM-5 (SCID-5)
preterm birth37 weeks of gestationdefined as delivery before 37 weeks of gestation

Countries

Italy

Contacts

Primary ContactGabriele Saccone, MD
gabriele.saccone.1990@gmail.com3394685179

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026