Cohort Study, Recurrent Acute Pancreatitis
Conditions
Keywords
recurrent acute pancreatitis, natural course, therapeutic effect
Brief summary
The goal of this observational cohort study is to learn about the etiology, natural course, therapeutic effect and outcome of recurrent acute pancreatitis patients. The main question it aims to answer is: Does endoscopic intervention, surgery or conservative treatment reduce the recurrence of acute pancreatitis? What are the risk factors affecting the recurrence of acute pancreatitis? Patients will be closely followed and clinical information will be recorded.
Detailed description
Acute pancreatitis is one of the most common causes of acute hospital admission, which is unpredictable and contributes to high health-care costs even death. Recurrent acute pancreatitis is defined as two or more discrete episodes of acute pancreatitis, and has an estimated annual incidence of 8-10 per 100 000. Cholelithiasis, alcohol and Hyperglyceremia are the most commonly recognized causes of acute pancreatitis. About 80% of RAP patients can be identified through routine investigations identify (include proper history, physical examination, CT, MRI, endoscopic ultrasound); however, in up to 20% of cases whose cause remains unclear are known as idiopathic RAP. For RAP patients with clear cause, removal of the cause can effectively reduce or prevent recurrence. For patients with idiopathic RAP, the treatment options are not clear and have been subject to debate. At present, the natural course, outcome and therapeutic effect of RAP is still not clear. Therefore, the prospective cohort can clarify the clinical characteristics of RAP more comprehensively and deeply and to accumulate evidence for treatment.
Interventions
COMBINATION_PRODUCTendoscopic intervention, surgery or conservative treatment
Personal information and treatment of the enrolled subjects will be collected.
Sponsors
Changhai Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with recurrent acute pancreatitis.
Exclusion criteria
* Unwilling or unable to provide consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence rate of acute pancreatitis | Through study completion, an average of 1 year | Acute pancreatitis is diagnosed according to the revised Atlanta classification, which requires 2 of the 3 following criteria: (1) abdominal pain suggestive of pancreatitis, (2) serum amylase and/or lipase greater than 3 times the upper limit of normal, (3) and crosssectional imaging (CT or MRI) findings consistent with acute pancreatitis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Characteristics of acute pancreatitis | Through study completion, an average of 1 year | Collect relevant data through medical record. Characteristics of acute pancreatitis includ etiology, frequency, severity and length of hospital. |
| Proportion of patients wtih pain in RAP patients | Through study completion, an average of 3 year | Collect relevant data through pain assessment scales which include severity, frequency, time of duration and other characteristics of pancreatic pain. |
| Proportion of patients with different treatment | Through study completion, an average of 1 year | Treatment mainly contains conservative treatment, surgery, endoscopic intervention, etc. Collect relevant data through medical record. |
| Evaluation of quality of life | Through study completion, an average of 3 year | The level of quality of life in RAP patients is measured using the SF-36. |
| Evaluation of psychological condition | Through study completion, an average of 3 year | The psychological condition of RAP patients is measured using DASS-21. |
| Proportion of patients with chronic pancreatitis | Through study completion, an average of 3 year | Proportion of patients who developed chronic pancreatitis. |
Countries
China
Contacts
Primary ContactLianghao Hu, M.D.
Backup ContactXiaoyu Zhou
Outcome results
None listed