Healthy
Conditions
Keywords
Nutrition, Probiotics, Whey protein
Brief summary
The aim of this intervention study is to investigate the effect of a specific postbiotic (Lacticaseibacillus rhamnosus GG = LGG) and whey protein on immunity, recovery, and weight management in young adults. The objective is based on previous knowledge about the health-promoting effects of these factors. A new goal is to study the combined effect of the postbiotic and whey protein. The results of the study can be utilized to promote the health of the young adults.
Detailed description
The study is a randomized, double-blind, 3-arm intervention involving young adults (n=160). Participants are randomized into three groups to receive different study product, and differences among the groups will be compared, for example, in terms of gut microbiota, weight changes, and inflammatory markers derived from blood samples.
Interventions
DIETARY_SUPPLEMENTPlacebo Comparator
Low-protein milk product
DIETARY_SUPPLEMENTWhey protein hydrolysate milk product
Milk product with whey protein hydrolysate
DIETARY_SUPPLEMENTPostbiotic and whey protein hydrolysate milk product
Milk product with whey protein hydrolysate and Lacticaseibacillus rhamnosus GG
Sponsors
Government Body Funding
University of Turku
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
17 Years to 28 Years
Healthy volunteers
Yes
Inclusion criteria
\- healthy
Exclusion criteria
* medicines and diseases that significantly affect the functioning of the stomach and intestines (e.g. irritable bowel syndrome) * antibiotic treatment within 3 months * asthma medication * milk allergy (protein); the study product is lactose-free * the participant must adhere to avoid the use of foods or nutritional supplements containing probiotics, and high-protein products, e.g. whey protein powders and high-protein snack bars
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentrations of inflammatory markers from the blood samples | At the baseline (week 0) and after eight weeks (last visit) | hs-CRP (High-Sensitivity C-Reactive Protein), haptoglobin, suPAR (soluble urokinase-type Plasminogen Activator Receptor) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weight of the participant | At the baseline (week 0), at four weeks and after eight weeks (last visit) | Weight |
| Waist circumference of the participant | At the baseline (week 0) and after eight weeks (last visit) | Waist circumference |
| Infections during the intervention | During intervention (Eight weeks) | Self-reported infections during the intervention |
| Development of physical fitness | At the baseline (week 0) and after eight weeks (last visit) | Based on walking test |
| Changes in the gut microbiota composition, diversity and function | At the baseline (week 0) and after eight weeks (last visit) | Gut microbiota composition and function in feces by metagenomics shotgun sequencing |
| Changes in recovery | During intervention (Eight weeks) | Monitoring recovery using a sports watch. |
| Blood pressure | At the baseline (week 0), at four weeks and after eight weeks (last visit) | Blood pressure |
| BMI | At the baseline (week 0), at four weeks and after eight weeks (last visit) | Body Mass Index (BMI) |
| Changes in the sleep quality | During intervention (Eight weeks) | Monitoring sleep quality using a sports watch. |
Countries
Finland
Outcome results
None listed