Periodontitis
Conditions
Brief summary
The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ß).
Detailed description
Bactericidal/permeability-increasing proteins (BPI) specific and powerful effect against Gram negative bacteria and their LPSs is completely observable in biological fluids such as plasma, serum, and whole blood. Objective: It is the evaluation of periodontal disease effect of BPI and interleukin-1 beta (IL-1 β) levels in gingival fluid before and after non-surgical periodontal treatment (NSPT)in patients with periodontal disease. Method: Thirty systemically healthy and non-smoking individuals with periodontitis were included in the study. Before NSPT, the clinical parameters of plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAS), bleeding on probing (BOP) were measured. The gingival fluid samples were taken using the paper strip method. The same procedures were repeated at 6 weeks and 6 months after non-surgical periodontal treatment. ELISA method was used for the analysis of the samples
Interventions
PROCEDURENon-surgical periodontal treatment
Scaling and root planing in two sessions over the course of a 48-hour period comprised the standard treatment procedure
Sponsors
Akdeniz University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
22 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
Systemically healthy, * Stage II or III, Grade A periodontitis * Having at least 20 permanent teeth (excluding third molars and any tooth loss induced by -non-periodontal causes).
Exclusion criteria
Smoking, * use of alcohol; pregnancy or lactation; intake ofantibiotics, steroidal or non-steroidal anti-inflammatory drugs within the last 6 months * having received periodontal treatment within the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gingival crevicular fluid Bactericidal/permeability-increasing proteins levels | through study completion, an average of 1 year | Gingival Crevicular Fluid Bactericidal Permeability Increasing Protein levels in periodonitis patients after Non-surgical periodontal treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gingival crevicular fluid interleukin-1Beta levels | through study completion, an average of 1 year | Gingival Crevicular Fluid IL-1β in periodonitis patients after Non-surgical periodontal treatment |
Countries
Turkey (Türkiye)
Outcome results
None listed