Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels

Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels in Infants Under 1 Year of Age Suspected of Systemic Bacterial Infection

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06354205

Enrollment

160

Registered

2024-04-09

Start date

2024-06-01

Completion date

2025-04-01

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Infections, Children, Only, Procalcitonin, Saliva

Keywords

procalcitonin, saliva, children, infection

Brief summary

Recently, it has been seen that investigations from saliva samples could be an alternative to those from blood samples. Saliva collection is a simple, non-invasive, cost-effective, and relatively easy method, making it potentially suitable as a new diagnostic tool in pediatric patients. In the current literature, elevated levels of saliva CRP, TNF-α, IL-6, and IFN-γ have been reported in inflammatory conditions. However, while there are animal studies suggesting the use of saliva PCT levels for focal diseases such as gingival inflammation and periodontitis and as a potential tool for non-invasive detection of sepsis, there is no human study regarding its use in systemic infections. The aim of this study is to evaluate the correlation between serum PCT levels and saliva PCT levels in children suspected of SBE and to determine the diagnostic value of saliva PCT.

Interventions

DIAGNOSTIC_TESTSliva Procalcitonin

Sliva Procalcitonin vs Blood procalcitonin

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

0 Years to 1 Years

Healthy volunteers

Inclusion criteria

* Being under one year of age * Having serum Procalcitonin (PCT) requested due to suspicion of systemic infection

Exclusion criteria

* Being over one year of age * Having a chronic illness that could cause elevation in inflammatory biomarkers * Taking any medication (such as antibiotics, immunomodulatory, or immunosuppressive drugs, etc.) that could affect inflammatory biomarkers * Diagnosis of gingivostomatitis

Design outcomes

Primary

Measure	Time frame	Description
Correlation	One year	the correlation between serum Procalcitonin (PCT) levels and salivary PCT levels

Secondary

Measure	Time frame	Description
Diagnose	One year	Diagnostic value of saliva PCT

Countries

Turkey (Türkiye)

Contacts

Primary ContactCaner Turan, PhD

drcanerturan@gmail.com+902323901510

Backup ContactSercan Cinarli

sercancinarli4@gmail.com+902323901001

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026