Mpox (Monkeypox)
Conditions
Brief summary
Mpox is caused by a virus that can be spread through touching the affected skin of someone who has the infection, touching sheets or clothes that has been used by someone with the infection, or breathing in particles of virus from someone who has the infection. Mpox infection can cause skin and flu-like symptoms, but can also cause very few symptoms, or no symptoms at all. While the number of participants with mpox symptoms can be tracked, little is known about how many people have mpox, but experience few or no symptoms at all. To do this, a Canadian sample of gay, bisexual and other men who have sex with men (GBMSM) who are participating in a randomized controlled trial will be screened for mpox symptoms. Screening will include questions about whether they may be experiencing any mpox symptoms, history of past diagnosis of mpox, sexual history, and vaccination history and awareness. Swabs will be taken to test for the presence of mpox virus, and a blood sample will be taken to test for antibodies. Approximately 450 individuals will be recruited. The results will be descriptive in nature.
Interventions
None listed
Sponsors
Unity Health Toronto
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Healthy volunteers
No
Inclusion criteria
\- Participants need to have been enrolled in an existing randomized clinical trial (NCT04762134)
Exclusion criteria
\- None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Asymptomatic prevalence | 2 weeks | To determine the prevalence of asymptomatic, pre-symptomatic and paucisymptomatic mpox infection (pooled and individually), in a population of GBMSM with anticipated high mpox risk and high prevalence of vaccination. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptomatic prevalence | 2 weeks | To determine the prevalence of symptomatic mpox infection in the study sample |
| Mpox seropositivity | 2 weeks | To determine the prevalence of mpox seropositivity (both for total antibody and for neutralizing antibody) in the study sample |
| Characteristics | 2 weeks | To identify clinical and demographic characteristics associated with asymptomatic and/or paucisymptomatic infection in the study sample |
| Characteristics of seropositivity | 2 weeks | To identify clinical and demographic characteristics associated with mpox seropositivity in the study sample |
Countries
Canada
Contacts
Primary ContactAbby Li, MSc
Outcome results
None listed