Acute Kidney Injury, Intensive Care Unit, Ultrasound
Conditions
Brief summary
The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury.
Detailed description
The main questions it aims to answer are: 1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation。 2. To explore the relationship between renal microcirculation and systemic hemodynamics。 3. To explore the value of quantitative evaluation of renal microcirculation changes by contrast-enhanced ultrasound in the diagnosis of acute kidney injury
Interventions
DIAGNOSTIC_TESTContrast-enhanced Ultrasound
Patients with acute kidney injury high risk factors (KDIGO 2012) will undergo a contrast-enhanced ultrasound within 24 hours of admission to the ICU
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age\>18 years old * First admission to ICU \< 24h after admission and expected ICU stay ≥48 hours * Acute kidney injury risk factors (KDIGO 2012) * Contrast-enhanced ultrasound
Exclusion criteria
* Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment * Kidney transplantation or renal malignancy * Terminal stage of malignant tumor * Pregnancy * Renal artery stenosis or renal vein thrombosis * The quality of CEUS images is poor, and quantitative analysis cannot be performed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury (according to KDIGO 2012 criteria) | Through study completion, an average of 7 days | Acute kidney injury occur or not |
Contacts
Primary ContactYuewei Zhang, Dr
Backup ContactLigang Cui, Dr
Outcome results
None listed