Non-cystic Fibrosis Bronchiectasis
Conditions
Brief summary
The aim of this study is to evaluate the role of procalcitonin in bronchoalveolar lavage as a biomarker for assessment of severity of non-CF bronchiectasis in children in correlation with other markers (functional and radiological severity )
Detailed description
• The severity of bronchiectasis will be assessed using forced expiratory volume in 1s (FEV1), and bronchiectasis severity scores which included bronchiectasis severity index (BSI) , FEV1, chronic colonization, extension of lobes and dyspnea which were performed to assess non-CF bronchiectasis patients. BSI score * This score incorporates 9 variables. The total score is calculated by summing the scores for each variable and can range from 0 to 26 points. According to the overall score, patients are classified into three classes: patients with low BSI score (0---4 points), intermediate BSI score (5---8 points), high BSI score (≥9 points) * chest X ray and HRCT of the chest: to assess the radiological severity of bronchiectasis using the radiological findings will be measured by assessing the most recent chest X ray and HRCT of the chest performed in the last six months using Bhalla score(10) * Culture and sensitivity from bronchoalveolar lavage for isolation of pseudomonas aeruginosa and any other organism. * Sputum procalcitonin level was measured in BAL samples using bronchoscopy. * Bronchoscopy: would be undertaken when the children were in a stable clinical condition as part of their annual review
Interventions
DIAGNOSTIC_TESTprocalcitonin
level of procalcitonin in bronchoalveolar lavage
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
1. Children of both sex 2. Children aged from 6-17 years old. 3. Documented diagnosis of non-CF bronchiectasis by confirmed bronchiectasis findings using high-resolution computed tomographic (HRCT) lung scanning, and clinical symptoms consistent with bronchiectasis with a negative sweat test
Exclusion criteria
1. Age less than 6 years or more than 17 years. 2. Children Diagnosed with cystic fibrosis bronchiectasis with confirmed positive sweat chloride test(6). 3. If there was a history of a recent exacerbation during the previous month preceding the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| procalcitonin level in bronchoalveolar lavage as a biomarker for assessment of severity of non-CF bronchiectasis in children | 2 years | comparison between procalcitonin level in Bronchoalveolar lavage and other markers of severity of bronchiectasis |
Contacts
Primary Contactmaram M amir, lecturer
Outcome results
None listed