Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia

Correlation Between qNOX Values of the CONOX Monitor and Analgesia Nociception Index (ANI) Values During General Anesthesia Conducted With Propofol and Remifentanil TCI

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06351072

Acronym

ANI

Enrollment

Registered

2024-04-08

Start date

2024-04-02

Completion date

2024-10-01

Last updated

2024-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia

Brief summary

qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia. No trials have compared them, so with this trial authors want to explore the correlations between them.

Detailed description

qNOX and ANI are two indexes evaluting the anaglesia conduction during general anesthesia. Even if the aim is the same (to measure the nociception level) these indexes utilize different algorithm: the qNOX is derived by the electroencephalogrm (EEG), the ANI is derived by heart rate variation. No trials have compared them, so with this trial authors want to explore the correlations between them, and if altered values of one of them is stronger related to postoperative pain and delirium.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 90 Years

Inclusion criteria

* Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and remifentanil (Eleveld model)

Exclusion criteria

* Neurological disease * Psychiatric disease * Obesity * Regional anesthesia performed

Design outcomes

Primary

Measure	Time frame	Description
Correlation between qNOX and ANI values	qNOX, ANI, pupoillometry values, propofol and remifentanil concentration during induction, intubation, after post-tetanic count at the trend-of-four and maintenance phase of general anesthesia detected with target controlled inusion will be paired.	qNOX and ANI values will be compared to check the correspondance in evaluting analgesia level

Secondary

Measure	Time frame	Description
Correlation between qNOX from CONOX and Analgesia nocicpetion index (ANI) values and postoperative pain	qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative pain, evalued with NRS score after 24 hours	Evaluate if qNOX or ANI values relate to postoperative pain
Correlation between qNOX from CONOX and analgesia nocicpetion index (ANI) values and postoperative delirium	qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative delirium, evaluated with CAM and 4AT score after 24 hours	Evaluate if qNOX or ANI values relate to postoperative delirium

Countries

Italy

Outcome results