Colorectal Cancer
Conditions
Keywords
Colorectal cancer, Natural orifice specimen extraction surgery, Minimally invasive surgery
Brief summary
Natural orifice specimen extraction surgery (NOSES) has gained widespread recognition among scholars and has gradually been promoted and popularized around the world. However, the development of NOSES is still in the exploratory stage and there is a lack of strong evidence from evidence-based medicine to support its feasibility and safety, which has greatly affected its clinical application and development. Based on this, at the call of Professor Xishan Wang, the Chinese NOSES Alliance conducted a large retrospective clinical study involving multiple centers. By summarizing the NOSES cases of nearly 100 centers in China, the study aims to clarify the current status of NOSES surgery in China. Additionally, a comprehensive analysis and summary was conducted by combining the basic information of NOSES patients, perioperative data, postoperative pathological data, and follow-up information to further demonstrate the safety and feasibility of NOSES in the treatment of colorectal cancer. This study also provides more real and objective evidence-based medicine support for the promotion and development of NOSES surgery.
Interventions
PROCEDURENatural orifice specimen extraction
We perform laparoscopic colorectal cancer resection, intracorporeal anastomosis and transanal or transvaginal specimen extraction
Sponsors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Pathological diagnosis of primary malignant tumor in the colon or rectum; 2. The surgery meets the definition in the Consensus of NOSES Experts in Colorectal Cancer;
Exclusion criteria
1. Postoperative pathological diagnosis does not belong to primary malignant tumors in the colon or rectum; 2. The surgery does not meet the definition in the Consensus of NOSES Experts in Colorectal Cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of short-term complication | 30 days after surgery | Rate of complications occurred within 30 days after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative blood loss | 7 days | Estimated blood loss during the surgery |
| Time to first flatus after surgery | 7 days | Time to first flatus after surgery |
| Time to first stool after surgery | 7 days | Time to first stool after surgery |
| Operative duration | 7 days | Total time of the operation |
| 3-year disease free survival | 3 year | 3-year disease free survival |
| 3-year overall survival | 3 year | 3-year overall survival |
| Length of stay after surgery | 7 days | Length of stay after surgery |
Countries
China
Contacts
Primary ContactXishan Wang
Backup ContactMingguang Zhang
Outcome results
None listed