Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Predictive Value of Serum Uric Acid to High Density Lipoprotein Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06349850

Enrollment

100

Registered

2024-04-05

Start date

2024-06-30

Completion date

2024-09-30

Last updated

2024-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Kidney Injury

Keywords

DKI

Brief summary

An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

Detailed description

Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.

Interventions

DIAGNOSTIC_TESTserum uric acid level to plasma HDL-c level ratio (UHR)

high UHR is considered to be a risk factor for development of DKI in type 2 DM

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Type 2 diabetic patients * willing and agreed to be included in the study

Exclusion criteria

* Type 1 DM patients * patients with active urinary sediment * patients with glomerulonephritis * patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease * patients with evidence of alternative kidney disease * patients with history of kidney transplantation * patients with end stage renal disease * patients with family history of non diabetic forms of kidney disease * patients with active malignancy * patients with established hemolytic disease * CKD patients requiring dialysis * patients taking drugs that interfere with serum uric acid level * patients taking drugs that alter serum lipids level * pregnancy * Refused to consent to this study

Design outcomes

Primary

Measure	Time frame	Description
Uric acid to HDL-c ratio (UHR)	6 months	asociation of high UHR with development of DKI in type 2 DM

Contacts

Primary ContactEldeeb E. Mohamed, Resident

deebbayern13@gmail.com01092700322

Backup ContactAli T. Ali, Professor

01005871047

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026