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Multiplex PCR for Severe Respiratory Infections During the COVID-19 Pandemic

Relevance of the Multiplex PCR Approach for Severe Respiratory Infections of Patients Hospitalized - Including an Intensive Care Unit, During the COVID-19 Pandemic

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06349707
Acronym
VirCoV+
Enrollment
18
Registered
2024-04-05
Start date
2024-04-01
Completion date
2024-06-01
Last updated
2025-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Viral Pneumonia

Keywords

respiratory virus

Brief summary

The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge.

Detailed description

The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge: * the main goal was to perform a retrospective investigation of the molecular virological tests in a University hospital, in order to identify non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022 during the circulation of SARS-CoV-2, for public health knowledge; * the secondary aim was to retrospectively analyze, for a small subgroup of patients from an intensive care unit, the files of patients with positive molecular virological tests for non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022, reporting the following standard-of-care data: (i) the identification of the viruses, (ii) bioclinical features, (iii) medical impact of virological results in real life.

Interventions

OTHERother: Observational

For 18 ICU patients, retrospective collection of routine bioclinical database (ICCA db)

Sponsors

Central Hospital, Nancy, France
Lead SponsorOTHER

Study design

Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* For adult patients, or minors 'via' parents, able to give consent - 18 intensive care patients

Exclusion criteria

* Non-inclusion in case of refusal

Design outcomes

Primary

MeasureTime frameDescription
Occurrence of positive viral PCR assays (not COVID-19) from hospitalizations for respiratory infections.18 months, retrospectivelyNumber of patients with positive virological molecular tests (multiplex respiratory panels) from the beginning of 2021 to mid-2022, with the nature of the viruses detected and the chronology of occurrence of positive tests.

Secondary

MeasureTime frameDescription
Real-life features of patients in Intensive care (from the whole population - Outcome 1) with positive viral PCR during infectious pneumonia.18 months, retrospectivelyFor the group of patients in Intensive Care: * (i) number of positive molecular virological tests detecting respiratory viruses by FilmArray Pneumonia test * (ii) associated bioclinical data * (iii) medical impact of virological results in real life - progression of the infection and duration of thehospitalization.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026