Hyperpigmentation
Conditions
Keywords
photobiomodulation, PIE, PIH, LED
Brief summary
The aim of this study is to explore the effect of medical LEDs (830 nm and 590 nm) in the prevention and treatment of PIE and PIH.
Detailed description
Evidence regarding the efficacy of LEDs for post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH) is limited. The aim of this study was to evaluate the efficacy of 830 nm and 590 nm LED phototherapies on PIE and PIH. Design of the study: 308 nm LED light (1.5 MED) induced an in vivo PIE/PIH model on the thigh of ten healthy subjects. 830 nm (60 J/cm2) and 590 nm LED (20 J/cm2) were irradiated respectively. For therapeutic irradiation, PIE/PIH model was induced on D1, and LEDs were irradiated on D0, 1, 3, 6 and 8. For preventive irradiation, LEDs were irradiated on D0, 1, 3, 6 and 8 and PIE/PIH model was induced on D9. Erythema index (EI), melanin index (MI), transdermal water loss (TEWL) and C-Cube photography were measured during 10-day follow-up visits.
Interventions
DEVICELED
308 nm LED light was utilized to induce an vivo PIE/PIH model on the thigh of subjects. The irradiation dose was 1.5 MED. Five circular experimental lesions measuring 1.5 × 1.5 cm were selected on the thighs, categorizing into five groups: control group, 830 nm LED treatment group, 590 nm LED treatment group, 830 nm LED prevention group and 590 nm LED prevention group. 830 nm LED and 590 nm LED were irradiated, respectively. For therapeutic irradiation, the PIH model was induced on D1, and 830 nm (60 J/cm2, 50 mW/cm2) and 590 nm LED (20 J/cm2, 20 mW/cm2) were irradiated on D0, D1, D3, D6 and D8, respectively. For preventive irradiation, 830 nm and 590 nm LED were irradiated on D0, D1, D3, D6 and D8, respectively, and the PIE/PIH model was induced on D9.
OTHERwithout any LED exposition
without any LED exposition
Sponsors
Yanjun Dan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
308 nm LED light was utilized to induce an vivo PIE/PIH model on the thigh of subjects. The irradiation dose was 1.5 MED. Five circular experimental lesions measuring 1.5 × 1.5 cm were selected on the thighs, categorizing into five groups: control group, 830 nm LED treatment group, 590 nm LED treatment group, 830 nm LED prevention group and 590 nm LED prevention group.
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy Asians; 2. 20-65 years old; 3. Fitzpatrick classification III-IV; 4. Sign the informed consent form.
Exclusion criteria
1. Have abnormal skin manifestations, such as pigment diseases, photosensitivity diseases and other allergic diseases; 2. Those with a history of abnormal systemic diseases, such as heart disease, liver disease, kidney disease, tumors, and mental illness; 3. Women who are preparing for pregnancy, pregnant or breastfeeding; 4. Have used photosensitizing drugs within two weeks before inclusion in this study; 5. Topical or systemic drugs may be used during this study; 6. bad habits, such as smoking, drinking, etc.; 7. Volunteers who have recently participated in other clinical trials;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| melanin index | at day 8 | The effect of LED treatment on PIH will be estimated by measure by C-CUBE. |
| erythema index | at day 8 | The effect of LED treatment on PIE will be estimated by measure by C-CUBE. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| transepidermal water loss (TEWL) | at day 8 | The effect of LED treatment on skin water loss will be estimated by measure by delfin. |
| elasticity | at day 8 | The effect of LED treatment on skin elasticity will be estimated by measure by delfin. |
Countries
China
Contacts
Primary ContactYanjun Dan
Outcome results
None listed