Nasopharyngeal Carcinoma Patients Treated With Curative Radiotherapy
Conditions
Brief summary
To investigate the incidence, predictive markers, and survival impact of massive nasal bleeding in nasopharyngeal carcinoma (NPC) patients who received curative radiotherapy (RT) with/without chemotherapy. A total of 1327 patients with previously untreated, biopsy-proven NPC, and no distant metastasis were retrospective reviewed. Investigators analyzed the occurrence rates of massive nasal bleeding between different characteristics and tried to identify important predictive factors. Investigators compared overall survival between patients with and without massive nasal bleeding by Kaplan-Meier method.
Interventions
OTHERPatients without massive nasal bleeding
No event of massive nasal bleeding after curative radiotherapy
OTHERPatients with massive nasal bleeding
Any event of massive nasal bleeding after curative radiotherapy
Sponsors
Taichung Veterans General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* previously untreated, biopsy-proven NPC * no distant metastasis
Exclusion criteria
* incomplete record of history or treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Massive Nasal Bleeding Rate | From date of radiotherapy until the date of first documented massive bleeding, assessed up to 360 months | Massive Nasal Bleeding Rate among different characteristics. Massive Nasal Bleeding was defined as unique blood loss \> 300 ml or recurrent blood losses \> 100 ml. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | From date of radiotherapy until the date of last clinic visit or date of death from any cause, whichever came first, assessed up to 360 months | Overall Survival |
Countries
Taiwan
Outcome results
None listed