Comparing Intrathecal Morphine With Modified Thoracoabdominal Nerve Block Through Perichondral Approach in Major Abdominal Surgery

Comparing Postoperative Analgesic Effects of Intrathecal Morphine With Modified Thoracoabdominal Nerve Block Through Perichondral Approach in Major Abdominal Surgery

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06346860

Enrollment

Registered

2024-04-04

Start date

2024-04-15

Completion date

2024-07-29

Last updated

2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid Use, Postoperative Pain

Keywords

intrathecal morphine, Modified Thoracoabdominal Nerve Block Through Perichondral Approach

Brief summary

Abdominal surgery causes severe postoperative pain due to retraction of the abdominal wall and direct manipulation of visceral organs. It leads to delayed postoperative recovery, increased postoperative morbidity and mortality. Intrathecal morphine, epidural analgesia and patient-controlled intravenous analgesia are used in postoperative pain management of abdominal surgeries. Intrathecal morphine is frequently used in many centers because it provides effective pain control. However; morphine has undesirable effects such as urinary retention, postoperative nausea and vomiting, and respiratory depression. Modified thoracoabdominal nerves block through perichondrial approach is a technique defined by the modification of the thoracoabdominal nerves block through perichondrial approach, in which local anesthetics are delivered only to the underside of the perichondral surface. The primary implication of this study is to compare postoperative pain scores and opioid consumption in patients undergoing major abdominal surgery with intrathecal morphine or modified thoracoabdominal nerves block through perichondrial approach.

Interventions

PROCEDURERegional Block Comparison

Comparing postoperative pain and opioid consumption in groups

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patients over 18 years old * Patients undergoing major abdominal surgery

Exclusion criteria

* Patients with solid organ dysfunction * Patients who receive opioid or corticosteroid medication prior to surgery * Patients with bleeding diathesis * Patients with psychiatric disorders * Patients who can not be contacted after surgery

Design outcomes

Primary

Measure	Time frame	Description
Comparison of postoperative opioid consumption between two groups via Patient Controlled Analgesia (PCA) device	48 hours	Intravenous patient-controlled analgesia (PCA) is a system of opioid delivery that consists of an infusion pump interfaced with a timing device. Intravenous morphine consumption will be recorded via PCA device, then it will be documented in mg/kg units.

Secondary

Measure	Time frame	Description
Postoperative pain assessment with Numeric Rating Scale (NRS)	48 hours	In a Numerical Rating Scale (NRS), patients are asked to choose the number
Comparison of the frequency of treatment related complications	48 hours	Bradycardia, hypotension, sedation, respiratory depression, urinary retention, itching, need for rescue analgesics.
Participant satisfaction	48 hours	Whether the patient is very pleased/ satisfied/ unsatisfied/ complainant with the pain treatment will be recorded.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026