Nasolacrimal Duct Obstruction
Conditions
Brief summary
The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge. The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery. Therefore, hemostasis is of great significance in performing DCR surgery. In this regard, the reduction of controlled hypotension and the control of hemodynamic responses of the body to stress effectively reduce the bleeding volume during surgery. Hence, there is no enough studies about controlled hypotension in DCR we decided to perform such a comparison between the effect of dexmedetomidine and labetalol in providing controlled hypotension during DCR surgery.
Interventions
DRUGDexmedetomidine
the reduction of controlled hypotension and the control of hemodynamic responses of the body
DRUGLabetalol
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* physical status I or II according to ASA classification, age between ( 18 - 60 years )
Exclusion criteria
* Patients with physical status other than 1 and 2 according to ASA classification as :Hypertension, Diabetes mellitus, Ischemic heart diseases, Severe anemia, COPD, History of stroke, Impaired liver or renal function, Increase intercranial tension. * Allergy to any of the drug included in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess non invasive blood pressure during DCR surgery To compare between the effect of dexmedetomidine and labetalol in providing controlled hypotension. | 5 months | Controlled Hypotension In Dacryocystorhinostomy Surgery By: Dexmedetomidine is a potent α2 adrenergic agonist. Labetalol is a beta-adrenergic blocker agent with alpha1 and beta-adrenergic receptors blocking action |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effectiveness of dexamedetomidine for prolongation of postoperative analgesia. | 5 months | Dexmedetomidine is a potent α2 adrenergic agonist. One of the highest densities of α2 receptors is located in the pontine locus cereleus, an important nucleus mediating sympathetic nervous system function. It has sedative, anxiolytic, hypnotic, analgesic, and sympatholytic properties. |
Countries
Egypt
Contacts
Primary ContactMohammad A Mahmoud, Resident
Backup ContactElhadad A Mousa, Professor
Outcome results
None listed