Sickle Cell Disease, Vaso-occlusive Crisis
Conditions
Brief summary
This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD). * The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD. * The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC. * The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.
Interventions
None listed
Sponsors
University of Pennsylvania
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Adult males and females aged 18-45 * Diagnosis of sickle cell disease * current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites * Able to read and understand English * Willing to comply with study procedures
Exclusion criteria
* Currently pregnant, pregnant within the last month, or seeking to become pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| C-reactive protein level | 1 month | Serum level of hs-CRP |
Countries
United States
Outcome results
None listed