Catheter Complications
Conditions
Brief summary
Diphenhydramine has H1-antihistamine action, it also possesses anti-muscarinic properties. Thus, diphenhydramine might be able to reduce the problem of catheter related bladder discomfort by inhibiting smooth muscle spasm of the urinary bladder via its anti-muscarinic action .
Interventions
DRUGDiphenhydrAMINE 50 Mg/mL Injectable Solution
injection of Diphenhydramine 50 Mg/mL
DRUGSaline
injection of saline
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
male patients aged more than18-80 years ASA I and II , upper ureteric stone removal under general anesthesia r
Exclusion criteria
overactive bladder cognitive impairment a neuropsychological disorder, bladder outflow obstruction urinary tract infection, , neurogenic bladder, operative time \> 6 h
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of catheter related bladder discomfort postoperative | UP TO 6 HOURE | * none, did not complain of any CRBD even upon asking. * mild, revealed only on questioning. * moderate, reported without questioning but not accompanied by any behavioral response. * severe, stated on their own and followed by behavioral responses such as a strong verbal response, flailing limbs, and even attempting to pull out the urinary catheter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| visual analog scale (VAS) | up to 6 hours | 0 (no pain) to 10 (the worst imaginable pain) |
Countries
Egypt
Outcome results
None listed