Cognitive Impairment
Conditions
Brief summary
Pentoxifylline can improve cognitive impairment after ischemic stroke, possibly by improving the level of cerebral blood flow, affecting the content of blood oxygen and metabolic substances in the brain, and then playing a protective role in the transmission of nerve electrical signals, and ultimately improving cognitive function. The patients with cognitive impairment and non-dementia PSCIND after ischemic stroke were randomly divided into two groups. In addition to the basic drugs of ischemic stroke, the patients were given pentothemine sustained release tablets and blank control respectively to observe the effects of pentothemine on cognitive function and neuronal electrical signals in the patients with ischemic PSCIND. It is expected to explore the possible internal biological mechanism by using transcranial Doppler, oxygen-dependent functional magnetic resonance imaging and craniocerebral magnetic resonance pop analysis. Finally, statistical correlation analysis was used to elucidate the specific mechanism of pentoxifylline in improving cognitive function of non-dementia patients with cognitive impairment after ischemic stroke.
Detailed description
Pentoxifylline can improve cognitive impairment after ischemic stroke, possibly by improving the level of cerebral blood flow, affecting the content of blood oxygen and metabolic substances in the brain, and then playing a protective role in the transmission of nerve electrical signals, and ultimately improving cognitive function.
Interventions
DRUGPentoxifylline
Take pentoxifylline 0.4 g twice daily
Sponsors
The First Hospital of Hebei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Han Chinese, age 40-80 years old, male and female, right-handed; * The diagnosis is consistent with the Expert Consensus on the Management of Cognitive Impairment after Stroke 2021; * NIHSS score 1-15 points; * Daily Living Ability Scale (ADL) ≥75 score; * The Informed consent signed by the patient or his legal representative
Exclusion criteria
* Can not cooperate with the examination (including neuropsychological tests and scale assessment); * There were memory disorders, dementia with lewy bodies and frontotemporal dementia before the onset of stroke events; * There were definite infectious diseases 2 weeks before admission; Have a serious mental illness, previous history of cancer, alcohol or drug abuse; * Use of drugs that may affect cognitive function, including sedatives, anti-anxiety drugs, hypnotics, nootropic drugs, and cholinoid drugs; * Can not accept brain MRI examination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pentoxifylline can improve cognitive impairment after ischemic stroke | 3 months | The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment.If the score is less than 26 points, it is considered to have cognitive impairment.Patient scores get higher after 3 months, we think pentoxifylline can improve cognitive impairment after ischemic stroke. |
Countries
China
Contacts
Primary ContactBing Han, Ph.D. degree
Backup ContactJiaying Rong, master
Outcome results
None listed