Head and Neck Cancer
Conditions
Brief summary
Predicting toxicity in elderly patients with head and neck cancer: validating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes.
Detailed description
We aim to analyze clinical and biochemical variables to prospectively create and validate an independ-ent predictive score to identify the probability of G3-5 toxicity in HNC elderly patients candidated to a curative treatment with radiation treatment +/- systemic treatment.
Interventions
None listed
Sponsors
European Institute of Oncology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
70 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged ≥ 70 years * Histological diagnosis of squamous cell or undifferentiated HNC in stage III-IV AJCC ed VIII (si-nonasal, nasopharynx, oral cavity, oropharynx, unknown primary with HPV pos, larynx and hy-popharynx) and candidated to curative non surgical treatment (radiotherapy alone, Chemora-diation with platinum salts; radiation+cetuximab) * Evaluable disease accordingly to RECIST criteria 1.1 * Willing of sign a written informed consent * Adequate organ function
Exclusion criteria
Patient with cancer in other sites than HN \< than 2 years except for prostate cancer cT1-2, Gleason 3+3, NIMBC, initial Non Melanoma Skin Cancer, in situ cervical cancer) * PS ECOG 3-4 * Patients who received systemic treatments in the past for other primary tumors
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predicting toxicity in elderly patients with head and neck cancer | 2 years | validating a disease-oriented toxicity predictive tool and integrating it with avail-able screening tools for better outcomes |
Countries
Italy
Contacts
CONTACTMaria Cossu Rocca, MD
CONTACTfrancesca lombardi
Outcome results
None listed