Patients Undergoing Laparoscopic Surgery
Conditions
Brief summary
This study will quantify the nociception using Analgesia Nociception Index (ANI) during general anesthesia and analyze the differences in EEG depending on the degree of nociception. Additionally, the investigators will quantify the nociception during recovery and analyze the differences in EEG depending on the degree of nociception.
Interventions
OTHERThere is no Intervention name to describe.
There is no Intervention name to describe.
Sponsors
Gangnam Severance Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Patients aged ≥ 19 undergoing laparoscopic surgery
Exclusion criteria
* Patients with arrhythmia * Patients with pacemaker implantation * Patients who have received a heart transplant * Patients taking medications that may affect ANI (antimuscarinics, alpha-agonist, beta blockers, etc.) * Patients with central nervous system disease (dementia, stroke, epilepsy, brain tumor, psychiatric disease, etc.) * Patients who cannot understand the consent form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between changes in ANI and EEG band power in response to surgical stimulation. | When the laparoscope is inserted | Correlation between changes in ANI and EEG band power in response to surgical stimulation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between changes in ANI and EEG band power in response to tracheal intubation | When the tracheal intubation is conducted | Correlation between changes in ANI and EEG band power in response to tracheal intubation |
| Correlation between changes in ANI and EEG connectivity in response to surgical stimulation | When the laparoscope is inserted | Correlation between changes in ANI and EEG connectivity in response to surgical stimulation |
| Correlation between changes in ANI and EEG connectivity in response to tracheal intubation | When the tracheal intubation is conducted | Correlation between changes in ANI and EEG connectivity in response to tracheal intubation |
| Correlation between changes in ANI, EEG connectivity and NRS in response to analgesic administration | When analgesic drug is administered in the PACU. | Correlation between changes in ANI, EEG connectivity and NRS in response to analgesic administration |
| Differences in EEG band power(Delta, Theta, Alpha, Beta, Gamma) during surgery between groups with large and small changes in ANI | From the beginning of surgery to the end of surgery | Differences in EEG band power(Delta, Theta, Alpha, Beta, Gamma) during surgery between groups with large and small changes in ANI |
| Correlation between changes in ANI, EEG band power and NRS in response to analgesic administration | When analgesic drug is administered in the PACU. | Correlation between changes in ANI, EEG band power and NRS in response to analgesic administration |
| Differences in EEG band power(Delta, Theta, Alpha, Beta, Gamma) during recovery between groups with large and small changes in ANI | From admission to the PACU to discharge from the PACU | Differences in EEG band power(Delta, Theta, Alpha, Beta, Gamma) during recovery between groups with large and small changes in ANI |
| Differences in EEG connectivity during recovery between groups with large and small changes in ANI | From admission to the PACU to discharge from the PACU | Differences in EEG connectivity during recovery between groups with large and small changes in ANI |
| Differences in EEG band power(Delta, Theta, Alpha, Beta, Gamma) depending on the type of inhaled anesthetic | From the beginning of surgery to the end of surgery | Differences in EEG band power(Delta, Theta, Alpha, Beta, Gamma) depending on the type of inhaled anesthetic |
| Differences in EEG connectivity depending on the type of inhaled anesthetic | From the beginning of surgery to the end of surgery | Differences in EEG connectivity depending on the type of inhaled anesthetic |
| Differences in ANI depending on the type of inhaled anesthetic | From the beginning of surgery to the end of surgery | Differences in ANI depending on the type of inhaled anesthetic |
| Differences in EEG connectivity during surgery between groups with large and small changes in ANI | From the beginning of surgery to the end of surgery | Differences in EEG connectivity during surgery between groups with large and small changes in ANI |
Countries
South Korea
Contacts
Primary ContactMyung Il Bae
Outcome results
None listed