Acute Kidney Injury, Lung Cancer, Surgery
Conditions
Keywords
Acute Kidney Injury, Lung Cancer, Video Assisted Thoracoscopic Surgery
Brief summary
This study aims to investigate the potential factors contributing to the development of Acute Kidney Injury (AKI) in patients undergoing pulmonary resection with Video Assisted Thoracoscopic Surgery (VATS) for lung malignancy. The study will focus on demographic data, laboratory parameters, perioperative fluid management, and haemodynamics. The research will be conducted at SBÜ Ankara Atatürk Sanatorium Training and Research Hospital. The study will involve patients who have given informed consent and will undergo VATS with standard anaesthesia monitoring. Anaesthesia management will follow our routine protocol in our clinic. Patients will be divided into two groups based on whether they have a more than 25% decrease in estimated glomerular filtration rate (t-GFH) and/or a 1.5-fold increase in serum creatinine and/or a 6-hour urine volume of less than 0.5 ml/kg/h. The patients will be divided into two groups based on this definition, and the risk factors between these groups will be analysed. The preoperative routine blood values, demographic data (age, gender, height, weight, and BMI), ASA physical status, smoking and alcohol habits, comorbidities, and regular medication use will be recorded. Intraoperative urine output and haemodynamic parameters will also be monitored. Routine blood gas analysis, blood urea nitrogen (BUN), glomerular filtration rate (GFR), albumin, haemoglobin, sodium, potassium, chlorine, and magnesium will be measured and recorded, along with urine output and t-GFH. Patients will be evaluated in the hospital on the day the surgeon calls for a postoperative check-up and on the 30th postoperative day to see if there are any complications.
Interventions
OTHERDuration of Surgery
Total surgery time in minutes
OTHERVolume of Fluid in Surgery
Fluid volume given during surgery in ml
OTHERBlood Loss
Blood loss during surgery in ml
Sponsors
Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Over 18 years of age, under 65 years of age, * American Society of Anesthesiologists (ASA) physical status 1-3, * Data of patients who will undergo wedge resection, segmentectomy or lobectomy with elective VATS due to lung malignancy will be examined prospectively.
Exclusion criteria
* Patients with a body mass index (BMI) less than 18.5kg/m2 or greater than 35 kg/m2, * Those with impaired renal function (the upper limit of the creatinine reference range is more than 50%; 1.3 mg/dL for men and 1.1 mg/dL for women), * A radiological examination was performed using radiocontrast material in the preoperative period, * Clinically and radiologically diagnosed with congestive heart failure and treatment has been started, * Having a history of pulmonary edema, * Those who have used steroids and non-steroidal anti-inflammatory drugs for a long time (exceeding 30 days), * Intubated to intensive care unit, * In need of massive peroperative blood transfusion, * Patients with deficiencies in the parameters examined will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glomerular Filtration Rate | 1 day | Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. |
| Serum Creatinine | 1 day | The creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys are working. Creatinine in the urine can be measured with a urine test. A measurement of the serum creatinine level is often used to evaluate kidney function. |
| Amount of Urine | 1 day | The amount of urine produced per hour according to the patient's weight |
Countries
Turkey (Türkiye)
Contacts
Primary ContactAli ALAGÖZ, professor
Outcome results
None listed