Acute Kidney Injury, Intensive Care Unit, Ultrasound
Conditions
Brief summary
The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are: 1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation. 2. To explore the relationship between renal microcirculation and systemic hemodynamics. 3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.
Detailed description
Quantitative analysis of cortical perfusion by contrast-enhanced ultrasound； Echocardiography； Quantitative results of renal artery and vein spectrum
Interventions
OTHERRenal microcirculation quantitatively assessed by Contrast-enhanced ultrasound
Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound before hospital discharge
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18 years old; * AKI was diagnosed \< 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours; * Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury; * Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).
Exclusion criteria
* Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment; * Kidney transplantation or renal malignancy; * Terminal stage of malignant tumor; * Pregnancy; * Renal artery stenosis or renal vein thrombosis; * Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure \>90mmHg).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum creatinine values and/or urine output | Through study completion, an average of 7 days | Complete recovery (defined as a return to normal serum creatinine and urine volume) and reversal of acute kidney injury (AKI) (more than 50% improvement in serum creatinine and/or urine volume from baseline), non-recovery included persistent AKI(no significant improvement or further increase in serum creatinine and/or urine volume, the need for dialysis, or death.) |
Countries
China
Contacts
Primary ContactYuewei Zhang, Dr
Backup ContactLigang Cui, Dr
Outcome results
None listed