Neohepatic Albumin-Bilirubin Scores on Renal Outcomes in Living-donor Liver Transplantation Recipients

Impact of Neohepatic Albumin-Bilirubin Scores on Renal Outcomes Following Living-donor Liver Transplantation: Propensity Score Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06340607

Enrollment

3422

Registered

2024-04-01

Start date

2012-01-05

Completion date

2022-12-31

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Chronic Kidney Diseases, Graft Failure

Brief summary

This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.

Detailed description

Acute kidney injury (AKI) after liver transplantation (LT) significantly affects patient and graft outcomes. The Albumin-Bilirubin (ALBI) score, an objective and sensitive index of liver function, has potential applicability in predicting outcomes following LT. This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* living donor liver transplantation recipients (≥18 years)

Exclusion criteria

* preoperative serum creatinine (sCr) \> 1.4 mg/dL, diagnosed CKD or hepatorenal syndrome (HRS), or hemodialysis at baseline

Design outcomes

Primary

Measure	Time frame	Description
acute kidney injury	within 7 days after surgery	determined by change in sCr according to the Kidney Disease: Improving Global Outcomes (KDIGO) definition (increase in sCr of ≥26.5 mmol litre-1 within 48h or ≥1.5 times baseline within 7 days after surgery

Secondary

Measure	Time frame	Description
chronic kidney injury	within 1 year after surgery	when renal function assessed by calculating estimated serum glomerular filtration using the abbreviated modification of diet in renal disease equation was \<60 mL/min/1.73 m2 for 3 months or more, irrespective of cause
graft failure	the graft failure at overall period (calculated from the date of surgery to the last follow-up) from the date of surgery (up to 10 years)]	graft failure

Countries

South Korea

Outcome results