Blood Glucose Fluctuations, Hunger
Conditions
Brief summary
The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only solution on markers of energy metabolism
Detailed description
The study is designed as a randomised cross-over intervention study with three arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, and a less sweet 7% sucrose solution w/o hesperetin on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers. To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors.
Interventions
OTHER10% Sucrose
10% sucrose corresponding to a regular soft drink
DRUGSucrose+ Hesperetin
Addition of hesperetin increases sweetness of 7% sucrose solution to match sweetness of 10% sucrose solution
OTHER7% Sucrose
7% sucrose to match the caloric content of the sugar-reduced hesperetin intervention
Sponsors
University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy * non-smoking * normal taste responses towards sweet taste
Exclusion criteria
* pregnancy or breast-feeding * regular smokers * disturbed glucose and/or lipid metabolism * regular intake of medication * known allergies against one of the test compounds * ageusia alcohol or drug addiction intake of antibiotics within the past 2 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood glucose concentration | 15, 30, 60, 90, and 120 minutes after drinking the test solution | Change compared to baseline in blood glucose concentration \[mg/dL\] in plasma samples after drinking the test solution |
| Change in appetite score | Difference between before and 120 minutes after drinking of the test solution | Change compared to baseline in the subjective rating of the individual feeling of hunger, fullness, as well as appetite for a snack or for something sweet on a unstructured, digital visual analog scale ranging from 0-10 cm in comparison to baseline |
| Change in food intake | 120 minutes after drinking of the test solution | Ad libitum food intake from a standardized breakfast |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in regulating hormones | 15, 30, 60, 90, and 120 minutes after drinking the test solution | Change compared to baseline in Insulin, Glucagon-like peptide 1, Gastric inhibitory polypeptide, and Polypetide Y concentrations \[mmol/L\] in plasma samples after drinking the test solution |
Countries
Austria
Outcome results
None listed