Unrecognized Condition
Conditions
Keywords
Male supplement, Sperm quality, Aging, Mitochondrial function, Sexual function
Brief summary
This study investigates the effects of a new supplement on sperm quality in men with poor sperm quality. Fifty patients will receive the supplement for three months, followed by semen analysis and assessment of sperm aging and mitochondrial function. Changes in sexual function and aging symptoms will also be evaluated.
Detailed description
Due to modern lifestyle factors such as high work pressure, stressful routines, and environmental pollution, there has been a significant decline in sperm quality among men, potentially leading to infertility. In response, various supplements have emerged claiming to enhance sperm quality. This prospective investigation aims to determine the efficacy of a new supplement in improving sperm quality among patients with poor sperm quality. The study will enroll 50 patients undergoing semen analysis at our reproductive center, administering the supplement over a three-month treatment period to those identified with poor sperm quality. Subsequent semen analysis will be conducted, alongside assessments of sperm mitochondrial metabolic function before and after supplement administration. Sexual function and aging symptoms will also be evaluated using the International Index of Erectile Function (IIEF-5) and the Aging Males Symptoms Scale (AMS) before and after the supplementation period. The study aims to compare differences in semen analysis, sperm mitochondrial metabolic function, sexual function, and aging symptoms before and after supplementation.
Interventions
DIETARY_SUPPLEMENTMale supplement
Participants will be administered supplements for a three-month treatment period
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Not meet the criteria of the 6th edition of the WHO manual for human semen analysis * BMI:18-30 kg/m2
Exclusion criteria
* Azoospermia * Varicocele * Chromosome anomaly * Malignancy * Using hormone therapy or supplements in recent 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Semen analysis | through study completion, an average of 1 year | semen concentration, motility and morphology |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| oxygen consumption of mitochondria | through study completion, an average of 1 year | oxygen consumption rate |
| mitochondrial function | through study completion, an average of 1 year | adenosine triphosphate production |
| sexual function | through study completion, an average of 1 year | International Index of Erectile Function (IIEF-5): a diagnostic tool for erectile dysfunction. The scores for the IIEF-5 range from 5 to 25. Higher scores mean a worse outcome |
| aging symptoms | through study completion, an average of 1 year | Aging Males Symptoms Scale (AMS): a simple and effective way to detect whether you may have andropause. Each item is rated on a scale of 1 to 5. There are 17 in total, so the minimum score is 17 and the maximum score is 85. Higher scores mean a worse outcome. |
Countries
Taiwan
Contacts
Primary ContactLi-Te Lin
Outcome results
None listed