Bone Diseases, Metabolic, Bone Mineral Density, Premature Ovarian Insufficiency
Conditions
Brief summary
Explore the bone metabolism characteristics of premature ovarian insufficiency.
Detailed description
Explore the bone metabolism characteristics of premature ovarian insufficiency, indexes includes serum levels of TRACP-5b and BALP, BMD values of lumbar spine L1-L4, left and right hip, left and right femoral neck et.al.
Interventions
DIAGNOSTIC_TESTTesting the serum levels of bone metabolic markers
Testing serum levels of TRACP-5b and BALP, BMD values of lumbar spine L1-L4, left and right hip, left and right femoral neck et.al.
Sponsors
Shi Yun
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
Patients diagnosed by Western medicine with premature ovarian insufficiency. 18 ≤ patients' age ≤ 39 years;. Patients who voluntarily participate in this study, sign an informed consent form.
Exclusion criteria
Patients with congenital gonadal dysplasia or a family history similar to early menopause. POI patients with acquired organic lesions or ovarian surgery. Patients who have taken Western or herbal medicine artificial cycle therapy or other endocrine therapy in the past three months. Patients with serious primary diseases and mental disorders such as cardiovascular and cerebrovascular, liver, kidney and hematopoietic system. Patients who are breastfeeding or pregnant.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| tartrate resistant acid phosphatase-5b, TRACP-5b | On the 2~4th day of menstruation (amenorrhea patients are collected when enrolled) | Blood samples are collected when enrolled. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bone specific alkaline phosphatase, BALP | On the 2~4th day of menstruation (amenorrhea patients are collected when enrolled) | Blood samples are collected when enrolled. |
| bone mineral density, BMD | On the 2~4th day of menstruation (amenorrhea patients are collected when enrolled) | BMD values of lumbar spine L1-L4, left and right hip, left and right femoral neck |
Countries
China
Outcome results
None listed