Colorectal Adenocarcinoma, Colorectal Cancer
Conditions
Keywords
colorectal cancer, pathological risk factors
Brief summary
Colorectal cancers (CRC) extending beyond the muscularis mucosae and invading the submucosa without extending beyond it are classified as pT1. Among these, a number of lesions presenting pejorative criteria, notably histopathological, have a significant risk of lymph node invasion, and are therefore candidates for partial colectomy with lymph node dissection. Tumors deemed to be at low risk of lymph node involvement can be treated by endoscopy alone. It should be noted that further surgical intervention is not without comorbid consequences, and that a significant proportion of post-surgical surgical specimens are free of cancerous lesions. The aim of this study is therefore to analyze the current histopathological criteria predictive of lymph node invasion, in order to more accurately select candidates for surgical management.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* Consecutive patients with pT1 colorectal cancer (of adenocarcinoma subtype only) diagnosed from January the 1st, 2009 to December the 31st, 2020, with first endoscopic resection, in the area of Finistère (France)
Exclusion criteria
* other than adenocarcinoma * other than T1 * primary surgical management * neoadjuvant treatment * refusal to data collection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of lymph node invasion rates as a function of tumor characteristics | 10 years |
Secondary
| Measure | Time frame |
|---|---|
| Population demographics | 10 years |
| lesion characteristics | 10 years |
| management | 10 years |
| recurrence | 10 years |
| survival | 10 years |
Countries
France
Outcome results
None listed