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Switching to E-cigarette After PCI

Prognostic Impact of Switching to E-Cigarette Use in Smokers With Coronary Artery Disease Following Percutaneous Coronary Intervention: A Nationwide Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06338761
Acronym
E-cig-PCI
Enrollment
17973
Registered
2024-04-01
Start date
2024-01-01
Completion date
2025-03-15
Last updated
2025-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Percutaneous coronary intervention, E-cigarette, Smoking

Brief summary

Despite the increasing popularity of electronic cigarettes (E-cigarettes), the prognostic impact of switching to E-cigarettes in smokers with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) remains uncertain.

Detailed description

Recently, several studies have reported that, although lower than combustible cigarette users, E-cigarette users had a significantly higher risk of future myocardial infarction (MI) or cardiovascular disease compared with non-smokers or quitters. However, because all previous studies has focused on the general healthy population, these results cannot be extrapolated for patients who already proven atherosclerotic cardiovascular disease (ASCVD), such as undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Although Busch et al. previously reported that a significant minority of patients are using E-cigarettes post-acute coronary syndrome smokers, a paucity of data exists regarding the impact of such transitions on clinical outcomes in current smoker patients with CAD who have undergone PCI. In light of these considerations, the current study sought to address this gap in knowledge by evaluating the prognostic implications of smoking habit changes, including E-cigarette use, among CAD patients with current smoking status following PCI.

Interventions

BEHAVIORALSmoking cessation

Stop smoking

Switching to E-cigarette

Sponsors

Samsung Medical Center
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* patients who underwent health screening 3 years before and after the PCI

Exclusion criteria

* history of cancer * history of ischemic stroke * died within the first 3 months of follow-up from the index date * Newly developed acute MI or received additional PCI or CABG from the index PCI date to the study index date

Design outcomes

Primary

MeasureTime frameDescription
MACE5 years after PCIMajor adverse cardiac event

Secondary

MeasureTime frameDescription
Cardiovascular death5 years after PCIdeath from cardiovascular cause
All-cause death5 years after PCIdeath from any cause
Spontaneous myocardial infarction5 years after PCIMI with hospitalization
Repeat revascularization5 years after PCIadditional PCI or CABG

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 5, 2026