Non-alcoholic Fatty Liver Disease NAFLD
Conditions
Keywords
non-alcoholic fatty liver disease, aerobic exercise, resistance exercise, bile acids, liver function
Brief summary
The purpose of this clinical trial is to investigate which exercise regimen is more effective in improving non-alcoholic fatty liver disease (NAFLD) in a young population. The primary questions it aims to answer are: Does aerobic training, resistance training, or a combination of both help improve liver function and glycemic and lipid parameters in NAFLD patients? Which of these three exercise regimens is more effective in improving the aforementioned parameters? Is the improvement in liver function related to bile acid metabolism? Participants will: Engage in physical exercise 4-5 times per week for two consecutive months, following a predefined exercise regimen. Have blood samples collected to test for glucose, lipids, liver function, and other parameters before starting the exercise program and after two months of completing the regimen.
Interventions
BEHAVIORALAerobic training (AT)
An exercise program was developed by a full-time physical education teacher, with all group exercises conducted at the outdoor track and field facility of Xuzhou Medical University. Participants in the aerobic training group, after completing a warm-up, were required to perform moderate-intensity aerobic running for 60 minutes per session, 4-5 times a week. The exercise intensity was set to reach 50%-70% of the maximum heart rate (Maximum heart rate = 220 - age). The exercise sessions were scheduled in the evening after dinner, from 17:30 to 19:00.All participants were continuously intervened for 8 weeks.
BEHAVIORALResistance training (RT)
Participants in the resistance training group were required to complete moderate-intensity resistance exercises 4-5 times per week. Each session included a warm-up, followed by exercises such as knee lifts with torso twists, knee-to-hand taps under the hips, jumping jacks, burpees, sit-ups, planks, and squats. The routine was structured to perform 5-6 exercises per session, with 6-8 repetitions for each set. There was a 30-second rest interval between sets, and the total exercise time was 60 minutes. The timing for these exercise sessions was the same as for the AT group, conducted in the evening after dinner.All participants were continuously intervened for 8 weeks.
BEHAVIORALCombined aerobic and resistance training (AT + RT)
Participants in the combined aerobic and resistance training (AT+RT) group started their sessions with a warm-up, followed by 30 minutes of aerobic running. After the aerobic training, they engaged in resistance training. The resistance training regimen was the same as that for the RT group, except that the duration of the resistance training was shorter. The total duration of the exercise session was 60 minutes.All participants were continuously intervened for 8 weeks.
Sponsors
Xuzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
After the data is obtained, the person analyzing the data will not know the specific grouping and participant information. The groups will be replaced by Group A, B, C, D, and the participants will be indicated by their IDs.
Intervention model description
The specific exercise plan and grouping are as follows: Participants were randomly (Using an electronic random number generator) divided into four groups: control group (Control), aerobic training group (AT), resistance training group (RT), and combined aerobic and resistance training group (AT + RT), with each group consisting of 10 individuals, totaling 40 participants. All participants were young adults aged between 18 and 21 years old.
Eligibility
Sex/Gender
ALL
Age
18 Years to 23 Years
Healthy volunteers
No
Inclusion criteria
* Body fat percentage \>20% or BMI \>24 * The diagnostic result of abdominal ultrasonography is fatty liver * No regular exercise under guidance in the past 3 months * No medication taken in the last month * No binge eating or heavy drinking in the past two weeks
Exclusion criteria
* Long history of alcohol consumption, equivalent to more than 30g/day of ethanol * Viral hepatitis * History of autoimmune or genetic diseases * History of drug-induced liver disease * History of total parenteral nutrition * History of cardiovascular, respiratory, or other diseases that necessitate avoidance of intense physical activity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in triglycerides compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in total bile acids compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in adenosine deaminase compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in high-density lipoprotein compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in low-density lipoprotein compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in body weight compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in Body Mass Index compared to baseline at 8 weeks | Baseline and 8 weeks | BMI |
| Changes in total cholesterol compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in alanine aminotransferase compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in aspartate aminotransferase compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in alkaline phosphatase compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in gamma-glutamyl transferase compared to baseline at 8 weeks | Baseline and 8 weeks | — |
| Changes in direct bilirubin compared to baseline at 8 weeks | Baseline and 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in percentage of body fat compared to baseline at 8 weeks | Baseline and 8 weeks |
| Changes in waist-to-hip ratio compared to baseline at 8 weeks | Baseline and 8 weeks |
| Changes in blood glucose compared to baseline at 8 weeks | Baseline and 8 weeks |
| Changes in the level of insulin compared to baseline at 8 weeks | Baseline and 8 weeks |
| Changes in albumin compared to baseline at 8 weeks | Baseline and 8 weeks |
| Changes in C-reactive protein compared to baseline at 8 weeks | Baseline and 8 weeks |
Other
| Measure | Time frame |
|---|---|
| Changes in other subtypes of bile acids compared to baseline at 8 weeks | Baseline and 8 weeks |
Countries
China
Outcome results
None listed