Alzheimer's Disease, Frontotemporal Degeneration (Semantic & Behavioral Variants)
Conditions
Keywords
Emotions, social cognition, social semantics, neuropsychology, frontotemporal dementia
Brief summary
Recent studies have shown that individual neuropsychological scores of patients with Alzheimer's disease and Associated Disorders (ADAD) are only poorly correlated to their behavioral difficulties, such as disinhibition, apathy, social decision-making or vulnerability. Recently, social & affective cognitive disorders have been highlighted as potential cause of social behavioral abnormalities. However, no previous studies have assessed the specific relationship between social & affective cognition & social behavior in ADAD. Our pilot study aims to explore the correlations between core and extended social & affective cognitive processes and social behavior as observed during the neuropsychological examination, as well as to explore the common brain regions involved in those domains.
Interventions
OTHERSCANN
Administering 11 tests of social \& affective cognition to each participant as well as 6 scales to their study-partner, in order to have a detailed profile of social \& affective cognitive abilities that we can correlate to an 3DMRI with resting state procedure.
Sponsors
University Hospital, Lille
France Alzheimer
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women; * 40 to 85 years of age (included); * Registered with the French Social Security; * Have a study partner. The study partner is required to complete several scales. If the subjects or their study partners are not able to drive, their transport fees will be reimbursed by the promotor. * Fluent in French, able to read and write;
Exclusion criteria
* Participants who have contraindications to perform an MRI scan; * Participants with significant sensory deficits that are not corrected by suitable devices. * Participants with dementia caused by a non-neurodegenerative disease, including patients with severe cerebrovascular risk factor load, in the judgment of the investigator; * Participants with other neurodegenerative disease such as Lewy body dementia and Parkinson's disease; * Participants with other serious neurological disorder such as brain tumor, stroke, epilepsy, hydrocephalus and any condition which contraindicates, in the investigator's judgment, entry to the study; * Participants with excessive alcohol intake or drug abuse, in the judgment of the investigator; * Participants who, in the opinion of the investigator, have a risk of non-compliance to the study procedures;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation coefficient between the mini Social cognition & Emotional Assessment - mini-SEA - total score and the Social Behavior Observer Checklist - SBOC - score in all participants. | 1day |
Secondary
| Measure | Time frame |
|---|---|
| Correlation coefficients between the mini Social cognition & Emotional Assessment - mini-SEA - sub scores and the neuropsychological assessment (as measured by the Social Behavior Observer Checklist - SBOC - score in all participants. | 1 day |
| Correlation coefficient between the SBOC score with MRI markers in all participants | 1 day |
| Correlation coefficient between mini-SEA sub scores & MRI markers in all participants. | 1 day |
| Correlation coefficients between mini-SEA sub scores with the SOCIAL50, CBI, ZBS, CSDC, SVS scales in each ADAD and controls groups. | 1 day |
| Correlation coefficients between SCANN sub-scores and the SBOC, SOCIAL50, CBI, ZBS, CSDC, SVS scales in each ADAD and controls groups. | 1 day |
Countries
France
Contacts
CONTACTThibaud LEBOUVIER, MD, PhD
PRINCIPAL_INVESTIGATORThibaud LEBOUVIER, MD, PhD
University Hospital, Lille
Outcome results
None listed