Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06338111

Enrollment

Registered

2024-03-29

Start date

2020-11-09

Completion date

2023-04-30

Last updated

2024-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biomarker, Emergency Department, Sepsis Syndrome

Keywords

Procalcitonin, Azurocidin 1, High Sensitivity C reactive protein, Urokinase-type plasminogen activator system, Soluble triggering receptor expressed on myeloid cells - 1, Interleukin-6, Severity scores, Emergency Department, Sepsis, Septic shock

Brief summary

This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly sensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and azurocidin 1 (AZU1) in 28-day mortality for patients with sepsis in Emergency Department.

Detailed description

The levels of the specified biomarkers were measured upon patient arrival at the Emergency Department (ED) and analyzed their correlation with 28-day mortality. The values of these biomarkers were monitored over the initial three days following admission to the ED, aiming to explore their potential in guiding the de-escalation of antibiotic treatment. Considering their prognostic significance, the main goal is to develop a novel scoring system tailored for use in the emergency department setting.

Interventions

DIAGNOSTIC_TESTELISA Sepsis Biomarkers dosage

Observational

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Sepsis 3 Criteria

Exclusion criteria

* individuals aged under 18 or above 90 * pregnant women * individuals in custody or deprived of their liberty * patients with associated pathologies such as severe trauma * other types of shocks * acute stroke * burns * pancreatitis myocardial infarction, pulmonary edema, status asthmatics, convulsions, drug overdose, those requiring emergency surgery * terminal stage of neoplastic disease

Design outcomes

Primary

Measure	Time frame	Description
Can we better predict mortality in septic patients from the Emergency Department?	03.2024-05.2024	Evaluation of the prognostic role of : IL-6, sTREM-1, suPAR, AZU1, hsPCR and PCT in predicting 28-day mortality in Emergency Department

Countries

Romania

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026