Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedema

Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedema:Cross Sectional Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06338059

Enrollment

200

Registered

2024-03-29

Start date

2024-03-01

Completion date

2024-06-01

Last updated

2024-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

B12 Deficiency Vitamin, Lipedema, Vitamin D Deficiency

Keywords

Vitamin D, B12 Deficiency Vitamin,Lipedema,Pain

Brief summary

Lipedema is a disease characterized by bilateral abnormal fat deposition in the upper and lower extremities. Pain is a common symptom in lipedema.Vitamin D plays an important role in chronic pain. Vitamin B have analgesic role in some neuropathic pain conditions.This study aimedto evaluate the relationship between vitamin D and vitamin B12 levels and neuropathic pain in lipedema.

Detailed description

In this cross sectional study 200 lipedema patients will beincluded. According to painDETECT questionnaire scores of cases with lipedema patients will be divided into two groups;An overall score of \> 13 likely or possible neuropathic pain (group 1) and \<13 unlikely NP (group 2). Patients' age, gender, comorbid diseases and laboratory values (25 OH vitamin D and vitamin B12 levels) will be recorded.

Interventions

OTHERVitamin B12 Level

Vitamin B12 Level Laboratory measurement of patient's vitamin B12 level in unit of pg/mL 25 OH Vitamin D Level Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 70 Years

Inclusion criteria

* The patients diagnosed byan experienced physical medicine and rehabilitation specialist for the diagnosis of lipedema

Exclusion criteria

* individuals who did not have 25(OH)D and B12 values in the past 6 months, * those with a history of gastrectomy or bypass surgery, * those consuming a vegetarian diet, those with lymphedema or chronic venous insufficiency, endocrine diseases, rheumatic diseases, malignancy, neurological diseases, and musculoskeletaldiseases that can be related to lower extremity neuropathic or nociceptivepain.

Design outcomes

Primary

Measure	Time frame	Description
Vitamin B12 Level	1 day	Laboratory measurement of patient's vitamin B12 level in unit of pg/mL
25 OH Vitamin D Level	1 day	Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026