Gestational Diabetes
Conditions
Brief summary
Gestational diabetes mellitus (GDM) is the development of glucose intolerance (GI) during pregnancy in a previously normoglycemic (NG) woman and associated with insulin resistance (IR). GDM is the most prevalent metabolic disorder during pregnancy and became a major public health problem for being usually diagnosed and detected after 24 gestational weeks (GW), while its complications can occur much earlier and this may explain its burden on maternal and fetal welfare. Human zonulin is a surrogate marker of intestinal permeability and can be utilized as biomarker for intestinal barrier function. Zonulin-mediated increase in intestinal permeability plays a role in the pathogenesis of insulin resistance, obesity, DM and metabolic syndrome. The increasing global prevalence of GDM with its associated risk of poor pregnancy and long-term risks for the mother and the offspring may lead to the production of new generation of diabetics.
Interventions
DIAGNOSTIC_TESTELISA
Estimation of Zonulin by ELISA from the Blood samples which were obtained at time of pregnancy .
Sponsors
Benha University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Newly Pregnant Women with singleton fetus
Eligibility
Sex/Gender
FEMALE
Age
22 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant Women with singleton fetus
Exclusion criteria
* Women with morbid obesity with body mass index ≥35 kg/m2; * Had manifest DM, irrespective of being controlled or not; * Bowel-related disorders; * Autoimmune disorders; * History of previous GDM.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Estimation of Gestational DM | 8 months | Relation between Serum Zonulin levels and Gestational Diabetes Mellitus |
Countries
Egypt
Outcome results
None listed