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Radiotherapy Treatments for Neoplasms of the Limbs

Radiotherapy Treatments for Neoplasms of the Limbs

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06335251
Enrollment
3000
Registered
2024-03-28
Start date
2018-02-22
Completion date
2025-12-31
Last updated
2025-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Metastases, Bone Neoplasms

Brief summary

In this observational study patients treated at European Institute of Oncology with radiotherapy to limbs will be included

Detailed description

Approximately 60% of patients with neoplasms receive radiotherapy as part of their oncological treatment. Various primary tumors as well as metastases of various origins can be localized in the upper or lower limbs. Patients with such neoplastic localizations will therefore receive radiotherapy treatment possibly associated with other systemic or surgical treatments. Treatment choice is usually established following multidisciplinary discussions, based on disease characteristics and stage, concurrent pathologies and pharmacological treatments, patient preferences, and functional aspects. Data collection related to radiotherapy plays a crucial role in understanding various clinical aspects of the treatment itself. The availability of data from an increasing number of patients will allow the identification of clinical situations or technical parameters of radiotherapy correlated with treatment tolerance and effectiveness, aiming to identify the best treatment for these oncological pathologies. This project aims to collect data related to radiotherapy treatments for primary or secondary neoplasms localized in the upper or lower limbs for scientific dissemination with the goal of establishing the basis for evaluating achieved results over time, and deriving from these elements useful for guiding the most effective treatment strategies and appropriate operational protocols.

Interventions

None listed

Sponsors

European Institute of Oncology
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Patients treated with radiotherapy for curative, palliative, neo-adjuvant, and adjuvant purposes in the upper and lower limbs for: Primary bone tumors, Primary soft tissue tumors, Primary tumors of the cardio-circulatory system, Primary tumors of the lymphatic system, Primary tumors of the nervous system and skin, Secondary metastases from various origins localized in that district. 2. Signed informed consent

Exclusion criteria

1\. Radiotherapy in districts other than limbs.

Design outcomes

Primary

MeasureTime frameDescription
Overall survival5 yearsNumber of patients death
Disease free survival5 yearsNumber of oncological event (local recurrence, distant metastasis, other primary tumor)

Countries

Italy

Contacts

Primary ContactBarbara Alicja Jereczek
barbara.jereczek@ieo.it+39 02 57489326

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026