Glymphatic System, Pediatric Disorder, Perivascular Disease, White Matter Disease
Conditions
Keywords
Glymphatic system, white matter disease, perivascular space, diffusion tensor imaging, gadolinium, rare disease
Brief summary
The dilation of perivascular spaces can be the result of various etiopathogenetic processes. White matter atrophy can cause enlargement of these perivascular spaces (PVS) but also obstruction of fluid drainage systems (interstitial fluid, ISF) and metabolites, as evidenced by some recent studies. Focal stagnation of liquids and deposition of toxic material induce tissue hypoxia and neuroglial dysfunction. Dilation of PVS can be associated with changes in white matter and microhemorrhages. We want to study these etiopathogenetic phenomena by implementing specific MRI methods.
Detailed description
Primary objective: the quantification of indirect magnetic resonance markers of altered waste drainage systems using validated scales in patients with white matter disease. Secondary objective: the evaluation of white matter alterations in relation to the known anatomical glymphatic pathways by analyzing both structural and diffusion data.
Interventions
DIAGNOSTIC_TESTMagnetic resonance imaging
Patients will undergo a magnetic resonance imaging for clinical purposes to which additional sequences. Post gadolinium research sequences will be acquired only if intravenous gadolinium needs to be administered for clinical purposes.
Sponsors
IRCCS Eugenio Medea
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
9 Months to 70 Years
Healthy volunteers
No
Inclusion criteria
* patients with and without white matter disease * patients willing to participate in research with signed consent form * no age limit (results will be age matched)
Exclusion criteria
* unwilling to participate in research
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extent of white matter lesions | once at recruitment | T1 values of lesions |
| Number of perivascular spaces | once at recruitment | count of perivascular spaces and total volume in disease population |
| Volume of parasagittal dural space | once at recruitment | volume of parasagittal dural space in disease population |
Countries
Italy
Outcome results
None listed