Biological Aging
Conditions
Keywords
Sleep, Chronotype
Brief summary
The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working out-of-phase with their chronotype are more likely to exhibit signs of depression and accelerated biological aging.
Detailed description
Understanding the relationship between chronotype, depression, and biological age is important in the field of sleep research and mental health. Sleep patterns and their alignment with an individual's internal body clock, or chronotype, have been increasingly recognized as influential factors in various aspects of well-being, including mental health and overall physiological aging. By conducting a study that investigates the potential correlation between chronotype, incidence of depression, and biological age, along with the impact of working out-of-phase with one's chronotype, the investigators can shed light on crucial aspects of sleep, mental health, and their interplay with biological aging.
Interventions
OTHERSurveys
Group will complete several surveys
Sponsors
University of Oxford
Elysium Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Has taken an INDEX test within the last 3 months * Has registered at least 1 INDEX kit via the Elysium Health website * Able and willing to provide digital consent to the RSCF, and the TIME-ZZZ Research Subject Consent Form
Exclusion criteria
* Consent to participate not given
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of being out of phase with chronotype on biological age | At baseline | Determine whether individuals working out-of-phase with their chronotype (from TIME-ZZZ survey responses) exhibit higher rates of biological aging compared to those working within their chronotype |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identification of DNA methylation markers associated with depression | At baseline | Identify specific DNA methylation markers associated with depression (from TIME-ZZZ surveys) potentially shedding light on the underlying epigenetic mechanisms involved in the development and progression of depressive disorders. |
| Effect of Chronotype Alignment and Depression Risk in Relation to Rate of Aging | At baseline | Determine the effect of chronotype alignment and depression risk (from TIME-ZZZ surveys) on biological rate of aging |
| Identification of DNA methylation markers associated with chronotype | At baseline | Identify specific DNA methylation markers associated with chronotype (from TIME-ZZZ surveys) thereby providing potential insights into the epigenetic regulation of sleep-wake patterns |
Contacts
Primary ContactRyan W Dellinger, PhD
Outcome results
None listed