Decreased Ovarian Reserve
Conditions
Brief summary
A prospective cohort study evaluated the clinical efficacy of Qingxin Zishen Decoction
Interventions
None listed
Sponsors
Yun Chen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
1.AMH AMH \<1.1ng/ml 2.AFC: AFC \<5\ 7 ovaries on both sides 3.Basic FSH: Basal FSH for two consecutive menstrual cycles ≥10 IU/L 4.Aged between 25 and 45 years old, female. 1. Those with reduced ovarian function caused by ovarian or uterine surgery, radiotherapy and chemotherapy; 2. Liver function (AST or ALT) and renal function (BUN or Ccr) are greater than 2 times the normal value; 3. Patients with a history of mental illness or legal disability 4. Those who have used endocrine-affecting drugs within 3 months before the study, estrogen, progesterone or related compound preparations, oral contraceptive pills, Chinese medicines or Chinese patent medicines related to the treatment of premature ovarian failure. Our hospital's preparations include Wu Turtle Rejuvenation Oral Liquid and Kuntai Capsules. 5. Patients with unexplained irregular vaginal bleeding 6. Patients who are participating in clinical trials of other drugs 7. For women who want to have children, those whose spouse's semen test fails to meet the standard will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum sex hormone levels | Keep truthful case records and medication records for patient during the initial diagnosis, 3rd month, 6th month and 12th month of treatment | SHBG stands for sex hormone binding globulin. It's a protein made mostly in your liver. It binds (attaches) to sex hormones in your blood. |
| Traditional Chinese medicine syndrome score | Keep truthful case records and medication records for patient during the initial diagnosis, 3rd month, 6th month and 12th month of treatment | Traditional Chinese medicine syndrome score |
| serum AMH levels | Keep truthful case records and medication records for patient during the initial diagnosis, 3rd month, 6th month and 12th month of treatment | An AMH test measures levels of anti-mullerian hormone, which corresponds to a person's egg count. |
| transluminal ultrasound evaluation of ovarian antral follicles and other parameters (AFC) | Keep truthful case records and medication records for patient during the initial diagnosis, 3rd month, 6th month and 12th month of treatment | Antral follicle count is rightly done on day 3 of the cycle by a Trans vaginal ultrasound. Initially the ovarian volume of both the ovaries is calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Seven items of thyroid function | Keep truthful case records and medication records for patient during the initial diagnosis, 3rd month, 6th month and 12th month of treatment | The thyroid gland produces hormones that regulate the body's metabolic rate, growth and development. It plays a role in controlling heart, muscle and digestive function, brain development and bone maintenance. |
| natural pregnancy rate | Keep truthful case records and medication records for patient during the initial diagnosis, 3rd month, 6th month and 12th month of treatment | A woman in her early to mid-20s has a 25-30% chance of getting pregnant every month. Fertility generally starts to slowly decline when a woman is in her early 30s, and after the age of 35 the decline speeds up. By age 40, the chance of getting pregnant in any monthly cycle is around 5%. |
Countries
China
Contacts
Primary ContactChen Yun
Backup ContactTEO YONG QING
Outcome results
None listed