Histiocytic Disorder
Conditions
Brief summary
This study is being done to collect medical and personal histories as well as a samples of blood, other body fluid and/or tumor/disease tissue for current and future research studies on histiocytic disorders.
Detailed description
PRIMARY OBJECTIVES: I. Define molecular signature and genomic landscape of histiocytic disorders. II. Correlate genomic findings with transcriptional abnormalities. III. Identify promising prognostic alterations and potential therapeutic targets. OUTLINE: This is an observational study. Patients complete questionnaires and undergo blood and tissue sample collection. Patients' medical records are also reviewed.
Interventions
OTHERNon-Interventional Study
Non-interventional study
Sponsors
Mayo Clinic
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
1 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients diagnosed with histiocytic disorders and age ≥1 year
Exclusion criteria
* \< 1 years age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identify molecular markers | Baseline | Biopsy samples will be analyzed for the presence of molecular markers associated with histiocytic disorders. Potential markers include BRAF V600E, cyclinD1, PD-L1, p16, and p53.6. For any test results that are actionable, patients will be notified and the results will be available in the electronic medical record. |
| Change in PD-L1 and T-cell Bim expression | Baseline; post-treatment (estimated up to 2 years, potentially 4 times per year) | Blood testing will be performed for soluble PD-L1 and T-cell Bim expressions before and after radiation therapy for histiocytic disease to assess change in levels and role of immunotherapy. For any test results that are actionable, patients will be notified and the results will be available in the electronic medical record. |
Countries
United States
Contacts
CONTACTClinical Trials Referral Office
PRINCIPAL_INVESTIGATORJithma P. Abeykoon, MD
Mayo Clinic in Rochester
Outcome results
None listed