Hepatocellular Carcinoma, Liver Transplantation, No-touch Technique
Conditions
Brief summary
The no-touch technique has been one of the most important principles of oncological surgery and aimed to prevent seeding and tumor cell dissemination. Previous studies in hepatectomy have shown that no-touch technique surgery can reduce HCC recurrence and improve the survival of patients. However, there is no consensus on whether the no-touch technique in LT for HCC improves the outcomes. This study aims to prospectively include liver transplant patients from multiple transplant centers, collecting their pre-transplant clinical information, post-transplant pathological records and exploring and clarify the correlation between no-touch technique and the prognosis of LT patients.
Interventions
PROCEDURELiver transplantation with No-touch technique
The core principle of no-touch tumor surgery revolves around avoiding direct contact with the tumor or surrounding tissues as much as possible to minimize the release of cancer cells into the bloodstream or nearby tissues.
Sponsors
Shulan (Hangzhou) Hospital
Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Diagnosis of HCC based on CT or MRI imaging or needle biopsy confirming a histologic diagnosis of HCC. 2. Patients undergoing deceased donor liver transplantation for the first time.
Exclusion criteria
(1) patients who received split LT or simultaneous transplantation, (2) patients who received re-transplantation, (3) patients with macroscopic portal vein tumor thrombosis or other macrovascular invasion, (4) patients with incomplete follow-up or incomplete important parameters records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence free surviavl rate | 2024.4.1-2028.4.1 |
| Overall survival rate | 2024.4.1-2028.4.1 |
| Tumor recurrence rate | 2024.4.1-2028.4.1 |
Outcome results
None listed